Results 71 to 80 of about 139,666 (219)
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Influence of Low-Level Jet intensity on aerodynamic loads of horizontal axis wind turbine rotor
Engineering Applications of Computational Fluid Mechanics, 2019 High wind speeds associated with Low-Level Jet (LLJ) make wind resources more favorable for wind energy production. However, the aerodynamic loads of large-scale horizontal axis wind turbine (HAWT) rotor under different LLJ inflow conditions have not ...
Xuyao Zhang, Congxin Yang, Shoutu Li
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Scheduling Information System at SMA N 1 Madang Rasuan OKU Timur
DinamisiaThe development of technology and information systems is currently so rapid, especially after the corona pandemic era, everything began to use technological assistance, not spared until the elements of the school were required to use technology as a ...
Dedy Kurniawan* +9 more
doaj +1 more source
FAST: Fast and Accurate Synoptic Texts
Digital Scholarship in the Humanities, 2019 Abstract Many classical texts are available in multiple versions that almost always differ from each other due to transcription error and editorial discretion. One of the central challenges in the study of such texts is the preparation of a ‘synoptic’ text: an aligned presentation of the various versions in which corresponding words or ...
Oran Brill, Moshe Koppel, Avi Shmidman
openaire +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Fast Association Tests for Genes with FAST
PLoS ONE, 2013 Gene-based tests of association can increase the power of a genome-wide association study by aggregating multiple independent effects across a gene or locus into a single stronger signal. Recent gene-based tests have distinct approaches to selecting which variants to aggregate within a locus, modeling the effects of linkage disequilibrium, representing
Chanda, Pritam +3 more
openaire +6 more sources
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source