Results 71 to 80 of about 1,575,789 (284)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Gradient-based and intra-frame adaptive depth decision algorithm

上海师范大学学报. 自然科学版, 2017
To reduce this computational complexity,agradient-based clipping algorithm for intra-frame candidatemode is proposed,which simplifies the intra prediction process by adaptive deep division and spatial information usage.Experimental results show that the ...
Shi Zhengcheng, Zhang Qian, Jing Ruihai, Cui Pengtao, Wang Bin, Yan Tao, Huang Jifeng   +6 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Fast Algorithms for $\ell_p$-Regression

, 2022
This paper is a coherent algorithmic framework that combines and simplifies our previous works: 1. arXiv:1901.06764 2. arXiv:1907.07167 3.
Adil, Deeksha, Kyng, Rasmus, Peng, Richard, Sachdeva, Sushant   +3 more
openaire   +2 more sources

A Fast Minimal Infrequent Itemset Mining Algorithm [PDF]

, 2014
A novel fast algorithm for finding quasi identifiers in large datasets is presented. Performance measurements on a broad range of datasets demonstrate substantial reductions in run-time relative to the state of the art and the scalability of the ...
Demchuk, Kostyantyn, Leith, Douglas J.
core   +1 more source

Algorithm and performance of a clinical IMRT beam-angle optimization system

, 2003
This paper describes the algorithm and examines the performance of an IMRT beam-angle optimization (BAO) system. In this algorithm successive sets of beam angles are selected from a set of predefined directions using a fast simulated annealing (FSA ...
Bortfeld T, Bortfeld T Stein J Preiser K, Braunstein M, Chuang K S, Crooks S M, Das S, David Djajaputra, Geman S, Jackson A, Kirkpatrick S, Llacer J, Mageras G S, Metropolis N, Oldham M, Pugachev A, Pugachev A B, Qiuwen Wu, Radhe Mohan, Rowbottom C G, Rowbottom C G, Rowbottom C G, Spirou S V, Stein J, Webb S, Webb S, Wu Q, Wu Q, Xiang Y, Xing L, Yan Wu   +29 more
core   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

A Fast and Simple Adaptive Bionic Wavelet Transform: ECG Baseline Shift Correction

Cybernetics and Information Technologies, 2016
An ECG baseline shift correction method is presented on the base of the adaptive bionic wavelet transform. After modifying the bionic wavelet transform according to the characteristics of the ECG signal, we propose a novel adaptive BWT algorithm.
Wang Ludi, Zhou Xiaoguang, Xing Ying, Liang Siqi   +3 more
doaj   +1 more source

Association of Corticospinal Tract Asymmetry With Ambulatory Ability After Intracerebral Hemorrhage

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ambulatory ability after intracerebral hemorrhage (ICH) is important to patients. We tested whether asymmetry between ipsi‐ and contra‐lesional corticospinal tracts (CSTs) assessed by diffusion tensor imaging (DTI) is associated with post‐ICH ambulation.
Yasmin N. Aziz, Carl D. Langefeld, Mary E. Comeau, Miranda C. Marion, Tyler P. Behymer, Lee A. Gilkerson, Padmini Sekar, Weihong Yuan, Vivek Khandwala, Brady J. Williamson, Thomas Maloney, Achala Vagal, Pierce Boyne, Kari Dunning, Matthew L. Flaherty, Steven J. Kittner, Prachi Mehndiratta, Gunjan Y. Parikh, Michael L. James, David Roh, Fernando D. Testai, Farhaan S. Vahidy, James Thornton, Ranjit Bagga, Daniel Woo, Stacie L. Demel   +25 more
wiley   +1 more source

A Highly Selective First-Level Muon Trigger With MDT Chamber Data for ATLAS at HL-LHC

, 2015
Highly selective triggers are essential for the physics programme of the ATLAS experiment at HL-LHC where the instantaneous luminosity will be about an order of magnitude larger than the LHC instantaneous luminosity in Run 1. The first level muon trigger
Kroha, H., Nowak, S.
core   +1 more source