Results 61 to 70 of about 3,952,753 (236)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

Reduced Biquaternion Windowed Linear Canonical Transform: Properties and Applications

open access: yesMathematics
The quaternion windowed linear canonical transform is a tool for processing multidimensional data and enhancing the quality and efficiency of signal and image processing; however, it has disadvantages due to the noncommutativity of quaternion ...
Hehe Yang   +4 more
doaj   +1 more source

The Fast Detection and Identification Algorithm of Optical Fiber Intrusion Signals

open access: yesAlgorithms, 2018
With the continuous development of optical fiber sensing technology, the Optical Fiber Pre-Warning System (OFPS) has been widely used in various fields.
Zhiyong Sheng   +3 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Efficient Intra Bitrate Transcoding for Screen Content Coding Based on Convolutional Neural Network

open access: yesIEEE Access, 2019
The Screen Content Coding (SCC) extension of High Efficiency Video Coding (HEVC) is developed to improve the coding efficiency of screen content videos. To meet the diverse network requirement of different clients, bitrate transcoding for SCC is desired.
Wei Kuang, Yui-Lam Chan, Sik-Ho Tsang
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

A New String Matching Algorithm for Searching Biological Sequences [PDF]

open access: yes, 2009
String matching algorithms play a key role in many computer science problems, and in the implementation of computer software. This problem has received, and continues to receive a great deal of attention due to various applications in text ...
Osborne, Hugh, Klaib, Ahmad
core   +4 more sources

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

open access: yesFEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour   +2 more
wiley   +1 more source

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