Results 61 to 70 of about 319,625 (266)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Enhancing HEVC Efficiency: A Novel Approach to Intra-Mode Estimation Through Hadamard Cost Analysis

IEEE Access
In the realm of video coding, the quest for enhanced efficiency is unending. This study introduces a novel optimization in High Efficiency Video Coding (HEVC) by refining intra-mode estimation through Hadamard cost analysis.
Junaid Tariq, Imran Javed, Touseef Sadiq, Hameedur Rahman, Ashfaq Hussain Farooqi, Amir Ijaz   +5 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Slim and Efficient Neural Network Design for Resource-Constrained SAR Target Recognition

Remote Sensing, 2018
Deep convolutional neural networks (CNN) have been recently applied to synthetic aperture radar (SAR) for automatic target recognition (ATR) and have achieved state-of-the-art results with significantly improved recognition performance.
Hongyi Chen, Fan Zhang, Bo Tang, Qiang Yin, Xian Sun   +4 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Gradient-based and intra-frame adaptive depth decision algorithm

上海师范大学学报. 自然科学版, 2017
To reduce this computational complexity,agradient-based clipping algorithm for intra-frame candidatemode is proposed,which simplifies the intra prediction process by adaptive deep division and spatial information usage.Experimental results show that the ...
Shi Zhengcheng, Zhang Qian, Jing Ruihai, Cui Pengtao, Wang Bin, Yan Tao, Huang Jifeng   +6 more
doaj   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

A Fast and Simple Adaptive Bionic Wavelet Transform: ECG Baseline Shift Correction

Cybernetics and Information Technologies, 2016
An ECG baseline shift correction method is presented on the base of the adaptive bionic wavelet transform. After modifying the bionic wavelet transform according to the characteristics of the ECG signal, we propose a novel adaptive BWT algorithm.
Wang Ludi, Zhou Xiaoguang, Xing Ying, Liang Siqi   +3 more
doaj   +1 more source