Results 51 to 60 of about 3,952,753 (236)
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Robust and fast algorithm for extracting the periodic feature from jet engine modulation signals
The Journal of Engineering, 2019 Jet engine modulation (JEM), a modulation phenomenon induced by the rotating structure of jet engines, is a representative feature extracted from the radar returns for aircraft target recognition.
Jingming Sun, Junpeng Yu
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Combined Randomized-Local Hough Transform versus UpWrite Transform in stamp detection [PDF]
Computer Science Journal of Moldova, 2003 The conventional Hough Transform used for detection of objects with known shape and size has proved its robustness. One typical task for this transform can be the detection of stamp(s) on an envelope.
Daniela Tondini
doaj
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
A Fast DOA Estimation Algorithm Based on Polarization MUSIC [PDF]
Radioengineering, 2015 A fast DOA estimation algorithm developed from MUSIC, which also benefits from the processing of the signals' polarization information, is presented. Besides performance enhancement in precision and resolution, the proposed algorithm can be exerted on ...
R. Guo, X. Mao, S. Li, Y. Wang, X. Wang
doaj
IEEE Access, 2017 A novel approach to segment corneal layer interfaces using optical coherence tomography images is presented. In this paper, we performed customized edge detection for initial location of interfaces, fitting the initial interfaces to circles via ...
Tianqiao Zhang +6 more
doaj +1 more source