Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
The benefit of textile design research to the textile designer. [PDF]
, 2010 If Textile Designers do not embark on and utilise textile research we will be left in a ‘sole less’ vacuum. The following article aims to show the benefit of textile design research to the textile designer. Textile design is increasingly complex, and
Montgomery, Bruce
core
Rapid adaptation of a polygenic trait after a sudden environmental shift
, 2017 Although a number of studies have shown that natural and laboratory populations initially well-adapted to their environment can evolve rapidly when conditions suddenly change, the dynamics of rapid adaptation are not well understood.
Jain, Kavita, Stephan, Wolfgang
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Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Greenwashing and bluewashing in the textile industry: Causes, consequences, and solutions for sustainable fashion [PDF]
Tekstilna industrijaThe textile industry is facing a growing issue of greenwashing and bluewashing, which are misleading environmental and social claims made by companies to appeal to customers' environmental and social consciousness.
Nahid-Ull-islam Md +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Sustentación de caso: propuesta de un plan estratégico del ingreso al mercado peruano de una empresa del sector fast fashion [PDF]
, 2018 Solange Salcedo Hermenegildo
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Factors Affecting Consumers Behavior of Coventry University Students Towards Fast-Fashion Industry [PDF]
, 2018 Erini Junita Sari, Hanifah Hanifah
openalex +1 more source
Nonequilibrium gating and voltage dependence of the ClC-0 Cl- channel. [PDF]
, 1996 The gating of ClC-0, the voltage-dependent Cl- channel from Torpedo electric organ, is strongly influenced by Cl- ions in the external solution. Raising external Cl- over the range 1-600 mM favors the fast-gating open state and disfavors the slow-gating ...
Chen, TY, Miller, C
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Coalescent approximation for structured populations in a stationary random environment
, 2010 We establish convergence to the Kingman coalescent for the genealogy of a geographically - or otherwise - structured version of the Wright-Fisher population model with fast migration. The new feature is that migration probabilities may change in a random
Jagers, Peter +2 more
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