Results 71 to 80 of about 1,029,548 (340)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

BARTHES EDITOR DE MODA

open access: yesRevista Criação & Crítica, 2015
Foi observando revistas e catálogos da alta moda que Barthes escreveu “O Sistema da Moda”. Esta curiosa análise levou à descoberta de novas simbologias e à criação de sistema original que identifica estruturas no espaço entre a roupa e a moda.
Salma Soria
doaj   +3 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Consumo: a engrenagem do fast fashion

open access: yesDAPesquisa, 2018
O presente artigo propõe uma análise, através de pesquisa bibliográfica e observação de lojas do setor estudado, para localizar na sociedade atual os elementos relacionados com o consumo que permitiram o estabelecimento do fast fashion.
Stella Lisboa Sapper
doaj   +1 more source

Direct measurement of molecular mobility and crystallisation of amorphous pharmaceuticals using terahertz spectroscopy. [PDF]

open access: yes, 2016
Despite much effort in the area, no comprehensive understanding of the formation and behaviour of amorphous solids has yet been achieved. This severely limits the industrial application of such materials, including drug delivery where, in principle ...

core   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Designing for Fast and Slow Circular Fashion Systems: Exploring Strategies for Multiple and Extended Product Cycles [PDF]

open access: yes, 2015
: This paper reviews work conducted by practiced-based textile design researchers based at the University of the Arts London (UAL) who were part of the multi-disciplinary, Swedish-based Mistra Future Fashion research consortium between June 2011 – May ...
Earley, Rebecca, Goldsworthy, Kate
core  

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Unsupervised empirical Bayesian multiple testing with external covariates

open access: yes, 2008
In an empirical Bayesian setting, we provide a new multiple testing method, useful when an additional covariate is available, that influences the probability of each null hypothesis being true.
Ferkingstad, Egil   +4 more
core   +2 more sources

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