Results 111 to 120 of about 594,792 (294)

A Comparator-Less Buck Converter with Fast Transient Response Using a Reactive Ramp Generator

Energies
This paper introduces a voltage-mode DC-DC buck converter designed to address the challenges of high-frequency operation. The proposed comparator-less Reactive Ramp Generator (RRG) topology mitigates the issues associated with comparator delays ...
Young-Kyu Kim, Chung-Hee Jang, Dong-Hyun Shin, Kwang-Hyun Baek   +3 more
doaj   +1 more source

Electrochemical response of biased nanoelectrodes in solution

, 2013
Novel approaches to DNA sequencing and detection require the measurement of electrical currents between metal probes immersed in ionic solution. Here, we experimentally demonstrate that these systems maintain large background currents with a transient ...
Chien, Chih-Chun, Di Ventra, Massimiliano, Doi, Kentaro, Kawai, Tomoji, Kawano, Satoyuki, Ohshiro, Takahito, Taniguchi, Masateru, Tsutsui, Makusu, Zwolak, Michael   +8 more
core  

Forcing and response in simulated 20th and 21st century surface energy and precipitation trends

, 2009
A simple methodology is applied to a transient integration of the Met Office Hadley Centre Global Environmental Model version1 (UKMO-HadGEM1) fully coupled atmosphere-ocean general circulation model in order to separate forcing from climate response in ...
Adler, Allan, Allan, Allen, Andrews, Andrews, Boer, Boer, Boer, Collins, Forster, Forster, Gregory, Gregory, Hansen, Hansen, Held, Lambert, Lambert, Lambert, Levitus, Meehl, Mitchell, Mitchell, Nakicenovic, National Research Council, Pielke, Previdi, Ramanathan, Randall, Richter, Romanou, Senior, Shine, Soden, Soden, Stott, Timothy Andrews, Wentz, Wild, Williams, Yang, Yokohata, Yu, Zhang   +44 more
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

A push–pull FVF LDO with full‐spectrum PSR and fast transient response

Electronics Letters
A push–pull low‐dropout regulator based on flipped voltage follower is proposed and designed in 65 nm CMOS, which has a push‐current mode and a pull‐current one.
Heng Zheng, Baixin Liu, Chen Wang, Xukun Wang, Bo Zhou   +4 more
doaj   +1 more source

Evaluation of Transient Response of Turbochargers and Turbines Using Database Method for the Nonlinear Forces of Journal Bearings

Lubricants, 2019
The paper extents the fluid film bearing database method to arbitrary fixed bearing profiles including floating ring bearings. The method is applied to evaluate rotordynamic response of an automotive turbocharger, modeled as rigid rotor, and of a turbine-
Athanasios Chasalevris, Jean-Charles Louis   +1 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

State-space model identification and feedback control of unsteady aerodynamic forces

, 2014
Unsteady aerodynamic models are necessary to accurately simulate forces and develop feedback controllers for wings in agile motion; however, these models are often high dimensional or incompatible with modern control techniques.
Brunton, Steven L., Dawson, Scott T. M., Rowley, Clarence W.   +2 more
core   +1 more source