Results 81 to 90 of about 594,792 (294)

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Transient impairment of the adaptive response to fasting in FXR‐deficient mice [PDF]

FEBS Letters, 2005
The farnesoid X receptor (FXR) has been suggested to play a role in gluconeogenesis. To determine whether FXR modulates the response to fasting in vivo, FXR‐deficient (FXR−/−) and wild‐type mice were submitted to fasting for 48 h. Our results demonstrate that FXR modulates the kinetics of alterations of glucose homeostasis during fasting, with FXR ...
Cariou, Bertrand, Van Harmelen, Kirsten, Duran-Sandoval, Daniel, Van Dijk, Theo, Grefhorst, Aldo, Bouchaert, Emmanuel, Fruchart, Jean Charles, Gonzalez, Frank J., Kuipers, Folkert, Staels, Bart   +9 more
openaire   +4 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Leveraging Hybrid Filter for Improving Quasi-Type-1 Phase Locked Loop Targeting Fast Transient Response

Energies, 2018
In renewable energy generation applications, phase locked loop (PLL) is one of the most popular grid synchronization technique. The main objective of PLL is to rapidly and precisely extract phase and frequency especially when the grid voltage is under ...
Yunlu Li, Junyou Yang, Haixin Wang, Weichun Ge, Yiming Ma   +4 more
doaj   +1 more source

Mechanisms and time scales of glacial inception simulated with an Earth system model of intermediate complexity [PDF]

, 2009
We investigate glacial inception and glacial thresholds in the climate-cryosphere system utilising the Earth system model of intermediate complexity CLIMBER-2, which includes modules for atmosphere, terrestrial vegetation, ocean and interactive ice ...
A. Ganopolski, C. Kubatzki, M. Claussen, R. Calov   +3 more
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Self-Powered, Highly Sensitive, High Speed Photodetection Using ITO/WSe2/SnSe2 Vertical Heterojunction

, 2018
Two dimensional transition metal di-chalcogenides (TMDCs) are promising candidates for ultra-low intensity photodetection. However, the performance of these photodetectors is usually limited by ambience induced rapid performance degradation and long ...
Majumdar, Kausik, Murali, Krishna
core   +1 more source

Ultra-Fast Flash Observatory: Fast Response Space Missions for Early Time Phase of Gamma Ray Bursts [PDF]

, 2013
One of the unexplored domains in the study of gamma-ray bursts (GRBs) is the early time phase of the optical light curve. We have proposed Ultra-Fast Flash Observatory (UFFO) to address this question through extraordinary ...
A. Jung, A.J. Castro-Tirado, A.J. Castro-Tirado, A.S. Krasnov, Akerlof, Akerlof, Aptekar, B. Grossan, Barthelmy, Bloom, Boella, Burd, C. Budtz-Jørgensen, C. Eyles, Costa, E.V. Linder, Ellis, Fishman, G.F. Smoot, G.W. Na, Gehrels, Groot, H. Lim, H.W. Park, I. Yashin, I.H. Park, I.H. Park, J. Gorosabel, J. Lee, J. Ripa, J.E. Kim, J.M. Rodrigo, J.N. Choi, J.W. Nam, Jeong, K.W. Min, Kim, Kostelecky, Kouveliotou, M.-H.A. Huang Huang, M.-Z. Wang, M.B. Kim, M.I. Panasyuk, MacFadyen, Molinari, N. Vedenkin, Nakar, Nam, Norris, P. Barrillon, P. Chen, P. Connell, Panaitescu, Park, Paul, Perley, Perna, Piran, Produit, Racusin, Ricker, Roming, Roming, S. Ahmad, S. Brandt, S. Dagoret-Campagne, S. Jeong, S. Svertilov, S.-W. Kim, Stoldosky, T.-C. Liu, Tanvir, V. Reglero, van Paradijs, Vestrand, Vestrand, Williams, Winkler, Y.J. Choi, Y.W. Kim, Zhang   +80 more
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Smart integrated adaptive centralized controller for islanded microgrids under minimized load shedding [PDF]

, 2017
In this paper, a smart integrated adaptive centralized controller is proposed for monitoring and controlling integrated renewable energy sources (RESs), both for intentional and unintentional islanding modes of operation for microgrids, as well as, for a
Azizipanah-Abarghooee, R., Booth, C., Hong, Q., Karimi, M., Terzija, V., Uppal, H.   +5 more
core   +1 more source