Results 61 to 70 of about 159,898 (259)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Power quality and electromagnetic compatibility: special report, session 2 [PDF]

, 2015
The scope of Session 2 (S2) has been defined as follows by the Session Advisory Group and the Technical Committee: Power Quality (PQ), with the more general concept of electromagnetic compatibility (EMC) and with some related safety problems in ...
Desmet, Jan, Heimbach, Britta, Renner, Herwig   +2 more
core   +1 more source

A quasi-analytical model for energy-delay-reliability tradeoff studies during write operations in perpendicular STT-RAM cell

, 2012
One of the biggest challenges the current STT-RAM industry faces is maintaining a high thermal stability while trying to switch within a given voltage pulse and energy cost.
Butler, William H., Ghosh, Avik W., Munira, Kamaram   +2 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Optimal Reactive Power Planning Using FACTS Devices for Voltage Stability Enhancement in Power Transmission Systems

Energy Science & Engineering
The increased demand for electricity has forced power systems to operate near their stability limits. Optimal reactive power planning (ORPP) can enhance voltage stability and provide much‐needed support for grid operation. Flexible AC transmission system
Rawan Abu Zeitawyeh, Ayman Faza
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Fundamental scaling laws of on-off intermittency in a stochastically driven dissipative pattern forming system

, 2001
Noise driven electroconvection in sandwich cells of nematic liquid crystals exhibits on-off intermittent behaviour at the onset of the instability. We study laser scattering of convection rolls to characterize the wavelengths and the trajectories of the ...
A. Joets, A. Joets, A. Lange, A. Čenys, D. L. Feng, E. Dubois-Violette, E. F. Carr, F. Rödelsperger, F. Xie, H. Amm, H. Amm, H. Amm, H. Bohatsch, H. Fujisaka, H. Fujisaka, H. Fujisaka, H. Fujisaka, H. Fujisaka, H. Fujisaka, H. L. Yang, H. L. Yang, H. M. Zenginoglou, H. Nakao, H. R. Brand, I. Rehberg, I. Rehberg, I. W. Smith, J. A. Kosmopoulos, J. F. Heagy, K. Fukushima, K. Kondo, K. Kondo, L. Kramer, M. Bouvier, M. Sauer, N. Platt, N. Platt, O. V. Gerashchenko, P. L. Papadopoulos, R. A. Kashnow, R. F. Fox, R. Müller, R. Müller, R. Williams, S. C. Venkataramani, S. C. Venkataramani, S. Kai, S. Kai, S. Kai, S. Miyazaki, S. Rasenat, S. S. Y. L. K. Vistin, T. John, T. Kawakubo, T. O. Carroll, T. Yamada, T. Yamada, U. Behn, U. Behn, U. Bisang, U. Bisang, W. Helfrich, W. Yang, Y. Pomeau, Z. Qu   +64 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source