Results 61 to 70 of about 9,353,259 (259)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

L-Index Sensitivity Based Voltage Stability Enhancement [PDF]

, 2017
Voltage stability is a long standing issue in power systems. Due to the requirements of on-line monitoring and high computation efficiency, L-index is used as voltage stability metric in this paper.
Minglei You, Sun, Hongjian, Qitao Liu, You, Minglei, Matthews, Peter, Peter Matthews, Liu, Qitao Liu, Hongjian Sun   +7 more
core   +1 more source

Integrating Voltage Stability Into the Static Security Region: A Unified Analytical Framework

IEEE Access
The increasing penetration of distributed and renewable generation has driven modern power systems closer to their technical limits, making voltage instability a key threat to grid reliability and reducing the operational margin for preventive control ...
Rafael Alberto Garcia Tinoco, Joao Alberto Passos Filho, Jonathan Munoz Tabora, Maximiliano Martinez   +3 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

A STATIC AND DYNAMIC TECHNIQUE CONTINGENCY RANKING ANALYSIS IN VOLTAGE STABILITY ASSESSMENT [PDF]

, 2013
The objective of the research is to compare between technique for determine the weak bus of the power system using static and dynamic contingency ranking analysis. Identification of the weak bus is very important for providing
Nizam , Muhammad
core  

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Voltage Stability Prediction on Power Networks using Artificial Neural Networks [PDF]

, 2018
 The objective of this paper is to predict the secure or the insecure state of the power system network using a hybrid technique which is a combination of Artificial Neural Network (ANN) and voltage stability indexes.
Das, Priyanath, Saha, Gitanjali, Chakraborty, Kabir   +2 more
core   +2 more sources