Results 121 to 130 of about 575,766 (316)

Fasting-induced attenuation of AKT1/TSC2 and AKT1/mTORC1 signaling does not correlate with mTORC1 activity under hypoxic conditions.

, 2018
(A) Ratio of p-AKT1 (S473) over total AKT1. (B) Ratio of p-TSC2 (S939) over total TSC2. (C) Ratio of p-TSC2 (T1462) over total TSC2. (D) Ratio of p-mTOR (S2448) over total mTOR. (E) Ratio of p-mTOR (S2481) over total mTOR.
S. E. Köhler (5746274), W. H. Lamers (5746268), A. M. W. J. Schols (5746265), R. C. J. Langen (5746277), C. C. de Theije (645587), D. Neumann (5746271)   +5 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Fasting-Induced Changes in Hepatic P450 Mediated Drug Metabolism Are Largely Independent of the Constitutive Androstane Receptor CAR.

, 2016
Hepatic drug metabolism by cytochrome P450 enzymes is altered by the nutritional status of patients. The expression of P450 enzymes is partly regulated by the constitutive androstane receptor (CAR).
Achterbergh, R., A Boelen, Mathot, R. A. A., A. Boelen (3150819), H-J Klümpen (3150822), Lammers, L. A., R Achterbergh, J A Romijn, Klümpen, H.-J., L. A. Lammers (3150810), J. A. Romijn (3150816), R A A Mathot, R. Achterbergh (3150813), Boelen, A., Romijn, J. A., R. A. A. Mathot (3150825), L A Lammers, H-J Klümpen, de Vries, E. M., E M de Vries, E. M. de Vries (3150807)   +20 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

The Book Fasting

, 1996
93 hlm, 17 ...
Abdul Qodir Ahmad Zain
core  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

FAST: Fast Audio Spectrogram Transformer

ICASSP 2025 - 2025 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP)
Accepted at ICASSP ...
Anugunj Naman, Gaibo Zhang
openaire   +2 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Extra levothyroxine dose in Ramadan maintained normal thyroid hormone levels in patients with hypothyroidism: a randomized controlled trial

Frontiers in Endocrinology
IntroductionThe management of hypothyroidism during Ramadan represents a tangible challenge as levothyroxine (L-thyroxine), the first-line treatment for hypothyroidism, must be administered on an empty stomach at least 30 min before a meal in order to ...
Nawal Al-Mutawa, Bashair M. Mussa, Suhair Akhlaq, Zeenat AbdulWahid, Ahmad Qawas   +4 more
doaj   +1 more source