Results 131 to 140 of about 626,053 (310)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Extra levothyroxine dose in Ramadan maintained normal thyroid hormone levels in patients with hypothyroidism: a randomized controlled trial

Frontiers in Endocrinology
IntroductionThe management of hypothyroidism during Ramadan represents a tangible challenge as levothyroxine (L-thyroxine), the first-line treatment for hypothyroidism, must be administered on an empty stomach at least 30 min before a meal in order to ...
Nawal Al-Mutawa, Bashair M. Mussa, Suhair Akhlaq, Zeenat AbdulWahid, Ahmad Qawas   +4 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Fasting-induced attenuation of AKT1/TSC2 and AKT1/mTORC1 signaling does not correlate with mTORC1 activity under hypoxic conditions.

, 2018
(A) Ratio of p-AKT1 (S473) over total AKT1. (B) Ratio of p-TSC2 (S939) over total TSC2. (C) Ratio of p-TSC2 (T1462) over total TSC2. (D) Ratio of p-mTOR (S2448) over total mTOR. (E) Ratio of p-mTOR (S2481) over total mTOR.
S. E. Köhler (5746274), W. H. Lamers (5746268), A. M. W. J. Schols (5746265), R. C. J. Langen (5746277), C. C. de Theije (645587), D. Neumann (5746271)   +5 more
core   +1 more source

Clinical Epidemiologic Study of Admissions due to Neurologic Diseases during and after Ramadan Fasting, Sari, Iran, 2015

Journal of Mazandaran University of Medical Sciences, 2019
Background and purpose: Studies on neurological diseases in Ramadan reported different incidence rates, diurnal pattern, and risk factors. This study aimed at comparing the incidence of neurological diseases and their related factors in Ramadan and ...
Nasim Tabrizi, Narges Karimi
doaj  

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

The Book Fasting

, 1996
93 hlm, 17 ...
Abdul Qodir Ahmad Zain
core  

Multicenter Survey of Ramadan Fasting among Cancer Patient and Healthcare Professionals in the I.R. Iran [PDF]

, 2018
Background: Muslim cancer patients and healthcare professionals face several challenges about the necessity of fasting and its possible side effects during the holy month of Ramadan.
Maleki, Farzad, Homaei Shandiz, Fatemeh, Nahvijou, Azin, Roshandel, Gholamreza, Zendehdel, Kazem, Toorang, Fatemeh, Ghanbari Motalgh, Ali, Sasanfar, Bahareh, Borhani, Samaneh, Marzban, Maryam, Mohammadzadeh, Davood, Kazemian, Ali, Mohagheghi, Mohammad Ali, Sedaghat, Zahra, Janbabaei, Ghasem, Rashidian, Hamideh, Majidi, Azam   +16 more
core  

Metabolic signatures of combined exercise and fasting: an expanded perspective on previous telomere length findings

Frontiers in Aging
IntroductionAging is a complex process marked by a gradual decline in physiological function and increased susceptibility to diseases. Telomere length is frequently regarded as one of the primary biomarkers of aging.
Shamma Almuraikhy, Khaled Naja, Najeha Anwardeen, Maha Sellami, Hadaia Saleh Al-Amri, Haya Al-Sulaiti, Haya Al-Sulaiti, Sara S. Bashraheel, Amina Ali Aden, Mohamed A. Elrayess, Mohamed A. Elrayess   +10 more
doaj   +1 more source