Results 111 to 120 of about 626,053 (310)
Fasting-induced control of mTORC1 activity by AMPK/TSC2 signaling is altered by hypoxia.
, 2018 (A) Ratio of p-AMPK (T172) over total AMPK. (B) Ratio of p-TSC2 (S1387) over total TSC2 (for total TSC2 see Fig 5B panel 6). (C) Ratio of p-GR (S211) over total GR. mRNA expression of GR target genes: (D) Glul, (E) Foxo1, (F) Klf15, (G) Redd1.
S. E. Köhler (5746274) +5 more
core +1 more source
Journal of Lipid Research, 2000 Long-chain acyl-CoA thioesterases catalyze the hydrolysis of acyl-CoAs to the corresponding free fatty acid and CoA. We recently cloned four members of a novel multigene family of peroxisome proliferator-induced genes encoding cytosolic (CTE-I ...
Mary C. Hunt +5 more
doaj +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Fasting-Induced Changes in Hepatic P450 Mediated Drug Metabolism Are Largely Independent of the Constitutive Androstane Receptor CAR. [PDF]
, 2016 Hepatic drug metabolism by cytochrome P450 enzymes is altered by the nutritional status of patients. The expression of P450 enzymes is partly regulated by the constitutive androstane receptor (CAR).
Achterbergh, R. +20 more
core +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
, 1997 We studied, by means of Doppler ultrasonography, the blood flow in the superior mesenteric artery in 12 untreated patients with celiac disease (nontropical sprue) and in 15 healthy controls; peak systolic velocity, end diastolic velocity, mean velocity ...
Caputo, Salvatore +4 more
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eLife, 2018 Leptin is critical for energy balance, glucose homeostasis, and for metabolic and neuroendocrine adaptations to starvation. A prevalent model predicts that leptin’s actions are mediated through pro-opiomelanocortin (POMC) neurons that express leptin ...
Alexandre Caron +10 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Are we achieving or missing the objectives of fasting? [PDF]
, 2019 As yet another blessed month of Ramadan unfolds, the perennial, and somewhat disturbing, truth re-emerges. That truth is that a great many Muslims fast. In many countries, overwhelming majorities – perhaps all -- do so.
Omer, Spahic
core