Results 71 to 80 of about 10,086,978 (282)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Body composition in patients with schizophrenia: Comparison with healthy controls

Annals of General Psychiatry, 2012
Background Recently, a relationship between obesity and schizophrenia has been reported. Although fat- mass and fat free mass have been shown to be more predictive of health risk than body mass index, there are limited findings about body composition ...
Sugawara Norio, Yasui-Furukori Norio, Tsuchimine Shoko, Fujii Akira, Sato Yasushi, Saito Manabu, Matsuzaka Masashi, Takahashi Ippei, Kaneko Sunao   +8 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Analyses of body composition charts among younger and older Chinese children and adolescents aged 5 to 18 years

BMC Public Health, 2012
Background Childhood obesity has become a major public health problem in China. The objective of this study was to examine the effect of age and sex on the relationship between fat-free mass (FFM) and fat mass (FM), fat-free mass index (FFMI) and fat ...
Xiong Kai-Yu, He Hui, Zhang Yi-Ming, Ni Guo-Xin   +3 more
doaj   +1 more source

Fat-free mass index in patients with chronic obstructive pulmonary disease

Journal of Physics: Conference Series, 2021
Abstract Chronic Obstructive Pulmonary Disease (COPD) is a public health problem because it is a major cause of death in the world. Approximately 25% of patients with moderate disease and 35% with severe disease show a reduced fat-free mass (FFM). Thus, the objective of this study is to define the correlation between fat-free mass index (
R A Díaz-Sanabria, C H González-Correa, F Marulanda-Mejía, C D Aguilar-Díaz, L E Sepúlveda-Gallego, L M Duque-González, M C Pineda Zuluaga   +6 more
openaire   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Fat-Free Mass Index in a Diverse Sample of Male Collegiate Athletes

Journal of Strength and Conditioning Research, 2019
Abstract Currier, BS, Harty, PS, Zabriskie, HA, Stecker, RA, Moon, JM, Jagim, AR, and Kerksick, CM. Fat-free mass index in a diverse sample of male collegiate athletes. J Strength Cond Res 33(6): 1474–1479, 2019—Fat-free mass index (FFMI) is a body composition metric that has been used to assess relative muscularity in athletes. Fat-free mass
Harty, PS, Zabriskie, HA, Stecker, RA, Currier, BS, Moon, JM, Jagim, AR, Kerksick, FACSM, CM   +6 more
openaire   +4 more sources

Assessing body composition by bioelectric impedance analysis and dual-energy X-ray absorptiometry in physically active normal and overweight Indian males

National Journal of Physiology, Pharmacy and Pharmacology, 2018
Background: To improve body composition measurement methods for physically active healthy individuals, validation with of bioelectric impedance analysis (BIA) with using dual-energy X-ray absorptiometry (DXA) on basis of variation in body mass index (BMI)
Daisy Masih, Gurseen Rakhra, Annu Vats, Saroj Kumar Verma, Yogendra Kumar Sharma, Som Nath Singh   +5 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source