Results 41 to 50 of about 35,491 (233)

Ultrasound-Based Attenuation Imaging for the Non-Invasive Quantification of Liver Fat - A Pilot Study on Feasibility and Inter-Observer Variability

IEEE Journal of Translational Engineering in Health and Medicine, 2020
Attenuation imaging is a novel, ultrasound-based technique to objectively detect and quantify liver steatosis. In this study, we evaluated the performance and inter-observer variability of attenuation imaging and compared it to a known quantification ...
Daniel Jesper, Daniel Klett, Barbara Schellhaas, Lukas Pfeifer, Moritz Leppkes, Maximilian Waldner, Markus F. Neurath, Deike Strobel   +7 more
doaj   +1 more source

Associations between the serum triglyceride-glucose index and pericoronary adipose tissue attenuation and plaque features using dual-layer spectral detector computed tomography: a cross-sectional study

Frontiers in Endocrinology, 2023
Background and aimsThe triglyceride-glucose (TyG) index is a reliable alternative marker for insulin resistance (IR). Pericoronary adipose tissue (PCAT) can indirectly reflect coronary inflammation.
Yue Ma, Yanhua Zhen, Min Wang, Lingfeng Gao, Yuxue Dang, Jin Shang, Xujiao Chen, Shaowei Ma, Ke Zhou, Kai Feng, Yang Xin, Yang Hou, Chuanji Guo   +12 more
doaj   +1 more source

A prospective study of image-based quantification of liver fat

Asian Journal of Medical Sciences
Background: Fatty liver disease involves triglyceride accumulation in hepatocytes, especially among obese and diabetic individuals. Diagnosis relies on a combination of history, examination, and imaging, with biopsy being a definitive but invasive ...
Elakkia Raja B , Manimekala E , Krishnaveni P   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

CT-based body composition analysis and pulmonary fat attenuation volume as biomarkers to predict overall survival in patients with non-specific interstitial pneumonia

European Radiology Experimental
Background Non-specific interstitial pneumonia (NSIP) is an interstitial lung disease that can result in end-stage fibrosis. We investigated the influence of body composition and pulmonary fat attenuation volume (CTpfav) on overall survival (OS) in NSIP ...
Luca Salhöfer, Francesco Bonella, Mathias Meetschen, Lale Umutlu, Michael Forsting, Benedikt M. Schaarschmidt, Marcel Opitz, Nikolas Beck, Sebastian Zensen, René Hosch, Vicky Parmar, Felix Nensa, Johannes Haubold   +12 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Perivascular Fat: A Novel Risk Factor for Coronary Artery Disease

Diagnostics
Perivascular adipose tissue (PVAT) interacts with the vascular wall and secretes bioactive factors which regulate vascular wall physiology. Vice versa, vascular wall inflammation affects the adjacent PVAT via paracrine signals, which induce cachexia-type
Spyridon Simantiris, Aikaterini Pappa, Charalampos Papastamos, Panagiotis Korkonikitas, Charalambos Antoniades, Constantinos Tsioufis, Dimitris Tousoulis   +6 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

High Inflammation and Coronary Calcification in an Acute Coronary Syndrome Successfully Treated with Cutting Balloon

Journal of Cardiovascular Emergencies, 2023
Complex coronary atherosclerosis may exhibit different phenotypes of coronary plaques, from non-calcified highly vulnerable atheroma to heavily calcified ones.
Blîndu Emanuel, Mátyás Botond-Barna, Bajka Balázs, Buicu Corneliu-Florin, Chițu Monica, Benedek Imre   +5 more
doaj   +1 more source