Results 51 to 60 of about 35,491 (233)

Association of Biologic Therapy With Coronary Inflammation in Patients With Psoriasis as Assessed by Perivascular Fat Attenuation Index [PDF]

JAMA Cardiology, 2019
Psoriasis is a chronic inflammatory skin disease associated with increased coronary plaque burden and cardiovascular events. Biologic therapy for psoriasis has been found to be favorably associated with luminal coronary plaque, but it is unclear whether these associations are attributable to direct anti-inflammatory effects on the coronary arteries.To ...
Youssef A, Elnabawi, Evangelos K, Oikonomou, Amit K, Dey, Jennifer, Mancio, Justin A, Rodante, Milena, Aksentijevich, Harry, Choi, Andrew, Keel, Julie, Erb-Alvarez, Heather L, Teague, Aditya A, Joshi, Martin P, Playford, Benjamin, Lockshin, Andrew D, Choi, Joel M, Gelfand, Marcus Y, Chen, David A, Bluemke, Cheerag, Shirodaria, Charalambos, Antoniades, Nehal N, Mehta   +19 more
openaire   +2 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Fat Accumulation, Liver Fibrosis, and Metabolic Abnormalities in Chinese Patients With Moderate/Severe Versus Mild Hepatic Steatosis

Hepatology Communications, 2019
Several drugs in development for nonalcoholic fatty liver disease (NAFLD) aim to decrease the amount of fat in the liver. We compared quantity and quality of fat in subcutaneous, visceral and muscle compartments, liver fibrosis, and prevalence of ...
Wei Zhang, Rui Huang, Yi Wang, Huiying Rao, Lai Wei, Grace L. Su, Anna S. Lok   +6 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Differences in different reconstruction algorithms for coronary CTA demonstrating pericoronary adipose tissue attenuation

Scientific Reports
The Fat Attenuation Index (FAI) surrounding the coronary arteries, a sensitive biomarker for coronary inflammation, can be measured through standard Coronary Computed Tomography Angiography (CCTA).
Yuxuan Zhu, Jiajie Zhu, Xin Ding, Yingying Ge, Dejiong Liu, Hongbing Ma   +5 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Prognostic efficacy of pericoronary fat attenuation index and fibrous plaque index in patients with acute coronary syndrome

陆军军医大学学报
‍Objective‍　‍To explore the predictive value of fat attenuation index (FAI) and fibrous plaque index (FPI) for the prognosis of patients with acute coronary syndrome (ACS).
HUANG Cong, WEN Feng, WANG Xinglan
doaj   +1 more source

Relationship Analysis Between Pericoronary Fat Attenuation Index and Parameters of Single Plaque

Journal of Computer Assisted Tomography
Objective The aim of the study is to investigate the relationship between plaque parameters and pericoronary fat attenuation index (FAI). Methods A retrospective collection was performed on 227 patients with coronary heart disease who underwent coronary computed tomography ...
Ji-Yan, Nie, Wen-Xi, Chen, Qing-De, Wu
openaire   +2 more sources

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source