Multivalent Protein Nanorings for Broad and Potent SARS‐CoV‐2 Neutralization
Advanced Healthcare Materials, EarlyView.A protein‐only, modular multivalent nanoscaffold displaying 20 anchor points, decorated with two different binders (10 of each), targeting the SARS‐CoV‐2 receptor‐binding domain is presented. The construct self‐assembles into stable, biocompatible, homogeneous nanoparticles, exhibit synergistic binding with fM IC50 values. It also detects spike at 9 ng
Molood Behbahanipour +11 more
wiley +1 more source
Association between relative fat mass and osteoarthritis in American adults. [PDF]
Front NutrLi Z +5 more
europepmc +1 more source
Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs
Advanced Healthcare Materials, EarlyView.Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner +8 more
wiley +1 more source
Body muscle mass versus fat mass: gender-specific associations with NAFLD and liver fibrosis. [PDF]
Lipids Health DisVolaklis K +3 more
europepmc +1 more source
Admixture/fine-mapping in Brazilians reveals a West African associated potential regulatory variant (rs114066381) with a strong female-specific effect on body mass- and fat mass-indexes [PDF]
, 2019 Marília O. Scliar +42 more
openalex +1 more source
Association between fat mass of trunk and limbs and arterial stiffness in hemodialysis patients
, 2023 Ayumi Shuto +10 more
openalex +2 more sources
Advanced Materials, EarlyView.A Janus‐engineered nanoplatform (J‐pHLIP‐PD1), featuring separate tumor‐ and immune‐targeting faces, bridges melanoma cells and cytotoxic T lymphocytes using toposelective pHLIP and anti‐PD‐1 presentation. This strategy elicits robust antitumor responses, promotes immunogenic tumor cell death, suppresses lung metastasis in vivo, and provides a modular,
Alba Ortuño‐Bernal +9 more
wiley +1 more source
Association between relative fat mass (RFM) and gallstones in adults: Results from NHANES 2017 to 2020. [PDF]
Medicine (Baltimore)Zhu W, Deng X, Jiang Y.
europepmc +1 more source
Recent Advances in Heterogeneous Frustrated Lewis Pair: Synthesis, Characterization, and Catalysis
Advanced Materials, EarlyView.This review provides a concise analysis of heterogeneous frustrated Lewis pair (FLP) chemistry, focusing on their synthesis, characterization, and application in small‐molecule activation. It highlights current challenges in developing solid FLP systems and explores promising advancements through emerging technologies, offering critical insights into ...
Jiasi Li +2 more
wiley +1 more source