Results 141 to 150 of about 365,594 (306)

De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

Advanced Science, EarlyView.
Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li, Haifan Gong, Yue Wang, Yinuo Zhao, Lixiang Li, Peijing Bao, Qingzhou Kong, Jialu Fu, Boyao Wan, Yumeng Zhang, Jinghui Zhang, Jiekun Ni, Zhongxue Han, Xueping Nan, Kunping Ju, Longfei Sun, Yuerui Ma, Huijun Chang, Mengqi Zheng, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +23 more
wiley   +1 more source

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

Advanced Science, EarlyView.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li, Ping Deng, Siyu Hou, Xianbo Xia, Wei Zhao, Xingyu Zhu, Yang Zhang, Chao Wang, Ling Xu, Jinlin Song   +9 more
wiley   +1 more source

Ultrasound evaluation of obesity: fat and muscle thickness, and visceral fat [PDF]

International Journal of Nutrology, 2012
Andrea, Z. Pereira, Marchini, Julio Sergio, Carneiro, Glaucia, Zanella, Maria Teresa   +3 more
openaire   +2 more sources

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Sphingomonas paucimobilis‐Driven Epithelial–Endothelial Transition in Adenomyosis Pathogenesis

Advanced Science, EarlyView.
This study identifies epithelial–endothelial transition (EET) as a novel adenomyosis pathogenic mechanism driven by Sphingomonas paucimobilis colonization. Systematic inhibitor experiments validate a TNFα→NF‐κB→MMP signaling cascade essential for EET. Critically, bacterial culture supernatant fails to induce pathological changes, demonstrating viable ...
Peigen Chen, Hao Shi, Junxian He, Ziyu Liu, Yuanyuan Zhu, Xiaoyan Liang, Guihua Liu, Xing Yang   +7 more
wiley   +1 more source

ANÁLISE ECONÔMICA, RENDIMENTOS DE CARCAÇA E DOS CORTES COMERCIAIS DE VACAS DE DESCARTE 5/8 HEREFORD 3/8 NELORE ABATIDAS EM DIFERENTES GRAUS DE ACABAMENTO

Ciência Animal Brasileira, 2012
The objective of this work was to study the effect of the fatness level on carcass and commercial cuts yields of 5/8 Hereford 3/8 Nellore cull cows, as well as to perform the economic analysis of the marketing of these cuts by the slaughterhouse industry.
Fabiano Nunes Vaz, Ricardo Zambarda Vaz, Leonir Luiz Pascoal, Paulo Santana Pacheco, Fabrícia Rocha Chaves Miotto, Natália Pinheiro Teixeira   +5 more
doaj  

Promotion of DFU Wound Healing via BRG1–COL16A1 Axis in Fibroblasts

Advanced Science, EarlyView.
In normal wound healing, transcription factor BRG1 is upregulated and binds the COL16A1 promoter to enhance its expression, promoting fibroblast proliferation, migration, contraction, extracellular matrix deposition, and granulation tissue formation, thus accelerating wound closure.
Penghui Wang, Jiaming Sun, Ying Wang, Bichen Ren, Yuxin Liu, Yunhan Liu, Liang Chen, Lu Yu, Tao Dai, Li Yu, Zhihui Dong   +10 more
wiley   +1 more source

Single‐Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis

Advanced Science, EarlyView.
This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu, Ting He, Yu Qian, Jia Li, Bowei Ni, Xiaojie Xu, Huanbo Wang, Peng Wang, Guoqing Cao, Siqi Ying, Guangyu Ding, Rong Wang, Zenghui Gu, Wei Li, Zhentao Man, Houfeng Zheng, Zhaohua Zhu, Zhen Li, Qingjun Meng, Chao Zheng, Liu Yang   +20 more
wiley   +1 more source

EVALUATION OF LEANNESS IN VIVO AND IN VITRO OF PIGS

Животновъдни науки, 2013
The study aimed to determine the accuracy of the measurements (fat thickness, depth of musculus longissimus (ML) and estimated lean meat) by ultrasound apparatus PIGLOG 105 compared with dissection (by the Weniger method) and the applicable regulations ...
ČEDOMIR RADOVIĆ, MILICA PETROVIĆ, NENAD BRKIĆ, BRANISLAV ŽIVKOVIĆ, NENAD PARUNOVIĆ, DRAGAN RADOJKOVIĆ, MARIJA GOGIĆ   +6 more
doaj  

Insights gained into the interpretation of surface electromyograms from the gastrocnemius muscles: A simulation study [PDF]

, 2011
Arabadzhiev, Blok, Dimitrova, Duchene, Eng, English, Farina, Farina, Farina, Farina, Farina, Gootzen, Kawakami, Kennedy, Lindstrom, Lowery, Luca Mesin, McLean, Merletti, Merletti, Merletti, Merletti, Merletti, Mesin, Mesin, Mesin, Mesin, Narici, Rainoldi, Reucher, Roberto Merletti, Roeleveld, Rosenfalck, Staudenmann, Stegeman, Taian M.M. Vieira, Tamaki, Vieira, Vieira, Vieira, Wolf   +40 more
core   +1 more source