Results 161 to 170 of about 365,594 (306)

Ultrasonographic Quantification of Reduction in Subcutaneous Fat Thickness Following Large-Volume Liposuction. [PDF]

Cureus
Sudha S, Biswal BS, Kumar V, Choudhary L, Dimri N, Panda R.   +5 more
europepmc   +1 more source

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

Correlation of Epicardial Fat Thickness With the Severity of Coronary Artery Disease. [PDF]

Cureus
Nagoni KB, Nandal R, Mathew M, Agrawal BK, Bhutani V.   +4 more
europepmc   +1 more source

Exploring the Relationship between Epicardial Fat Thickness and Coronary Revascularization: Implications for Cardiovascular Health. [PDF]

J Clin Med, 2023
Romano AD, La Marca A, Villani R, Sangineto M, Manuppelli V, Brunetti ND, Vendemiale G, Serviddio G.   +7 more
europepmc   +1 more source

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

Advanced Science, EarlyView.
TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang, Huishi Tan, Senhui Weng, Yuntao Liu, Lingxu Song, Shaoyu Cheng, Zelong Lin, Jiawei Chen, Fei Tan, Jun Wang, Jinke Huang, Linkun Cai, Jiwei Chai, Cailing Zhong, Yanqiang Shi, Wendi Zhang, Haiyan Zhang, Chongyang Huang   +17 more
wiley   +1 more source

Laparoscopic Appendectomy Is Superior in Patients with Higher Fat Thickness. [PDF]

JSLS
Teke E, Besler E, Özdilek HB, Akyüz C, Aydın Aksu S, Tilki M, Gürleyik MG.   +6 more
europepmc   +1 more source

A Bottom‐Up Design Framework for Multifunctional Lattice Metamaterials

Advanced Science, EarlyView.
This study introduces a generative AI framework for designing multifunctional lattice metamaterials. The method combines 3D Gaussian voxel generation with deep learning, enabling greater design freedom and structural performance. The optimized lattice metamaterials achieve enhanced energy absorption by 40–200% compared to conventional structures and ...
Zongxin Hu, Quanqing Tao, Junhao Ding, Shuo Qu, Haitao Ye, Jun Wei Chua, Tianxiao Niu, Rui Li, Winston Wai Shing Ma, Haoming Mo, Hui Liu, Wei Zhai, Xinwei Li, Xu Song   +13 more
wiley   +1 more source

Perirenal Fat Thickness Is Associated With Disturbed Circadian Blood Pressure Rhythm in Essential Hypertension. [PDF]

J Clin Hypertens (Greenwich)
Wu S, Chen L, Zheng Y, Shen Y, Jin J, Tang J, Wang L.   +6 more
europepmc   +1 more source

Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple‐Negative Breast Cancer by Disrupting the Hippo‐YAP/TEAD4‐PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation

Advanced Science, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) exhibits addiction to chronic endoplasmic reticulum (ER) stress, which sustains an aggressive metastatic phenotype through activation of the unfolded protein response (UPR). Here, we identify a previously unrecognized “ER‐stress addiction” axis in which the Hippo pathway effector TEAD4 directly ...
Yini Shang, Wentao Si, Youxue Zhang, Jialin Liu, Huaixi Zhang, Yafei Li, Hongmeng Su, Wei Jiang, Zhishan Ding, Lihong Wang   +9 more
wiley   +1 more source

C5 Subcutaneous Fat Thickness Ratio Predicts Surgical Site Infection After Cervical Laminoplasty: A Propensity Score-Matched Study. [PDF]

Global Spine J
Wu Y, Xu S, Liang Y, Zhang C, Li H, Zhang J, Zhu J, Zhang H, Liu H, Wang K.   +9 more
europepmc   +1 more source