Results 31 to 40 of about 82,312 (308)

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu   +8 more
wiley   +1 more source

High-resolution 3D weld toe stress analysis and ACPD method for weld toe fatigue crack initiation [PDF]

open access: yes, 2019
Weld toe fatigue crack initiation is highly dependent on the local weld toe stress-concentrating geometry including any inherent flaws. These flaws are responsible for premature fatigue crack initiation (FCI) and must be minimised to maximise the fatigue
Chaudhuri, Somsubhro   +3 more
core   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Slip Irreversibility, Microplasticity, and Fatigue Cracking Mechanism in Near-α and α + β Titanium Alloys

open access: yesMetals
The micromechanisms “slip transfer, slip irreversibility, microplasticity, and fatigue cracking” in titanium alloys are reviewed, with a special emphasis on near-α and α + β alloys.
Adam Ismaeel   +8 more
doaj   +1 more source

Premature fracture of high-strength suspension springs caused by corrosion fatigue cracking

open access: yesResults in Engineering, 2022
In this work, the mechanisms responsible for the premature fatigue fracture of four suspension springs during road test were investigated. Failure analysis combined with finite element method (FEM) and stress corrosion cracking (SCC) experiments were ...
J.Z. He   +4 more
doaj   +1 more source

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela   +13 more
wiley   +1 more source

Fatigue life of hot mix asphalt mixtures [PDF]

open access: yes, 2011
Fatigue cracking is one of the major types of distress in asphalt concrete pavements. Under the action of repeated vehicular loading, the asphalt concrete deteriorates and eventually results in fatigue cracking.
Abdulridha, Ammar Ali
core  

Mechanistic Analysis and Economic Benefits of Fiber-Reinforced Asphalt Overlay Mixtures [PDF]

open access: yes, 2020
Among the various distresses in flexible pavement structures, rutting and fatigue cracking can be accounted as two of the major distresses that need to be addressed by pavement engineers.
BASTOLA, Nitish   +3 more
core  

Comparison of shot peening and nitriding surface treatments under complex fretting loadings [PDF]

open access: yes, 2006
Considered as a plague for numerous industrial assemblies, fretting associated with small oscillatory displacements is encountered in all quasi-static contacts submitted to vibrations.
Fouvry, S.   +2 more
core   +2 more sources

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi   +2 more
wiley   +1 more source

Home - About - Disclaimer - Privacy