Results 41 to 50 of about 44,248 (260)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Three-dimensional correlation of damage criticality with the defect size and lifetime of externally impacted 25CrMo4 steel

Materials & Design, 2020
Modern railway axles frequently experience external damages, which results in deteriorated fatigue performance and a need for careful maintenance. Herein, the shot peening (SP)-induced strengthening of high-speed railway axle EA4T alloy or 25CrMo4 steel ...
Yan Luo, Shengchuan Wu, Xin Zhao, Yanan Hu, Cunhai Li, Zhao Shen, Xiangli Zhong   +6 more
doaj   +1 more source

An Improved Nonlinear Cumulative Damage Model Considering the Influence of Load Sequence and Its Experimental Verification

Applied Sciences, 2021
According to the change characteristics in the toughness of the metal material during the fatigue damage process, the fatigue tests were carried out with the standard 18CrNiMo7-6 material.
Wei Wang, Jianmin Li, Jun Pan, Huanguo Chen, Wenhua Chen   +4 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall, Kimberly Kwei, Rolando J. Acosta, Bharatkumar Koyani, Erin Robertson, Pratyush Rai, Roland Barge, Emily Timm, Nicollette L. Purcell, Natasha Desai, Dhanesh Patel, Ana‐Maria Visoiu‐Knapp, Samuel Stuart, Rinol Alaj, Matthew F. Wipperman, Oren Levy, Joan A. O'Keefe   +16 more
wiley   +1 more source

Accumulation of Fatigue Damage Using Memory of the Material

Procedia Materials Science, 2014
AbstractThis work proposes a new model for cumulation of fatigue failures based on material memory, developed on the grounds of memorising senseless material. Cumulation of fatigue failures (D) is based on employing time history of the trajectory and cumulation of fatigue failures with the help of a coefficient dependent on material memory.
Böhm, Ewelina, Kurek, Marta, Junak, Grzegorz, Cieśla, Marek, Łagoda, Tadeusz   +4 more
openaire   +1 more source

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

Numerical Analysis of Resource Characteristics of Structural Elements under Thermocycling Loading [PDF]

Journal of Applied and Computational Mechanics
We discuss methodological aspects of assessment of the service life of structures and devices used in new technologies, paying a particular attention to non-stationary thermomechanical loading of “dangerous” zones of the systems under investigation.
Leonid Igumnov, Ivan Volkov, Andrey Volkov, Victor Eremeyev   +3 more
doaj   +1 more source

Strain-based theoretical fatigue damage model of woven glass-epoxy fabric composite material

Composites Part C: Open Access, 2020
Strain-based theoretical fatigue damage model is developed by utilizing internal variable theory of thermodynamics of continuum damage mechanics approach related to woven glass fabric composite material.
Indra Narayan Yadav, Dr. Kamal Bahadur Thapa   +1 more
doaj   +1 more source