Results 71 to 80 of about 492,585 (315)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Mechanics of fretting fatigue tests

International Journal of Mechanical Sciences, 1987
A popular fretting fatigue test, in which oscillating tension is applied in phase with the fretting force, is analyzed. The configuration is a generalization of the well-known Mindlin contact problem, and it is shown that the addition of bulk tension has a substantial effect on the stick- slip geometry and the shear traction at the interface.
Nowell, D, Hills, D
openaire   +1 more source

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp, Ludwig Karrasch, Helena Breitenstein, Andreas Straube, Katharina Kamm   +4 more
wiley   +1 more source

Effect of sliding contact on fatigue properties of low alloy steel

Nihon Kikai Gakkai ronbunshu, 2019
Stress distribution of brake disks during braking is complicated due to sliding contact and frictional heat. To investigate the effect of sliding contact on the fatigue properties of low alloy steel, a new fatigue test method that enables the application
Yuiko SAKAYAMA, Takanori KATO, Taizo MAKINO, Miyuki YAMAMOTO   +3 more
doaj   +1 more source

Advancing Age Modulates Associations Between Cognitive Impairment and Brain Volumes in Early MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Cognitive impairment is common in multiple sclerosis (MS), but manifestations following the first demyelinating event are relatively unexplored. We investigated cross‐sectional associations between magnetic resonance imaging (MRI)–derived brain volumes and the presence of cognitive impairment outcomes five years after the first ...
Piriyankan Ananthavarathan, Marco Pitteri, Michael Foster, Sara Collorone, Sara Salama, Elisa Colato, Ferran Prados, Baris Kanber, Marios Yiannakas, Claudia A. M. Gandini Wheeler‐Kingshott, Indran Davagnanam, Frederik Barkhof, Declan Chard, Olga Ciccarelli, Ahmed Toosy   +14 more
wiley   +1 more source

The Association between Daytime Napping and Cognitive Functioning in Chronic Fatigue Syndrome

, 2015
OBJECTIVES The precise relationship between sleep and physical and mental functioning in chronic fatigue syndrome (CFS) has not been examined directly, nor has the impact of daytime napping.
Zoe M Gotts, Vincent Deary, Nicola Barclay, Jason G Ellis, Ellis, Jason, Deary, Vincent, Barclay, Nicola, Newton, Julia, Julia L Newton, Gotts, Zoe   +9 more
core   +1 more source

Weld residual stress effects on fatigue crack growth behaviour of aluminium alloy 2024-T351 [PDF]

, 2008
The interaction between residual stress and fatigue crack growth rate has been investigated in middle tension and compact tension specimens machined from a variable polarity plasma arc welded aluminium alloy 2024-T351 plate.
Liljedahl, CDM, Tan, M. L., Edwards, Lyndon, Irving, PE, Brouard, J, Liljedahl, C.D.M., Zanellato, O., Fitzpatrick, M. E., Zhang, Xiang, Fitzpatrick, M.E., Brouard, J., Ganguly, S, Liljedahl, C. David M., Ganguly, S., Zanellato, O, Irving, P.E., Lin, J., Tan, ML, Liljedahl, C. D. M., Edwards, L., Fitzpatrick, Michael E., Zhang, X.; id_orcid, Ganguly, Supriyo, Zhang, X., Zhang, X, Edwards, L, Zanellato, Oliver, Lin, J, Irving, P. E., Irving, Phil E., Tan, M.L., Fitzpatrick, ME   +31 more
core   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source

Motion Synchronous Composite Decoupling with Fewer Sensors on Multichannel Hydraulic Force Control for Aircraft Structural Loading Test System

Sensors, 2018
The aircraft full-scale fatigue test is widely used in the modern aircraft industry for the safety of flight. Generally, the aircraft full-scale fatigue test is achieved by structural loading; multiple hydraulic actuators are used to apply load for force
Yaoxing Shang, Ning Bai, Lingzhi Jiao, Nan Yao, Shuai Wu, Zongxia Jiao   +5 more
doaj   +1 more source

CAR T‐Cell Therapy in Neurology: A Scoping Review of Neuro‐Oncology, Autoimmune Diseases & Neurotoxicity

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi, Mohammed Dibas, Patricia Tai, Ala Dibas, Osama Souied, Suhair Al‐Ghabeesh   +5 more
wiley   +1 more source