Results 81 to 90 of about 1,070,597 (314)

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

Construction of best-fit fatigue curves considering material properties and loading modes (Translated)

Mechanical Engineering Journal
In this study, best-fit fatigue curves are constructed considering material properties and loading modes. Three common fatigue test methods (rotating bending, axial load-control, and strain-control) are compared, and their scopes of application are ...
Masahiro TAKANASHI, Seiji ASADA, Hideo KOBAYASHI   +2 more
doaj   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Analysis of fatigue strength of titanium-steel flange connection bolts in ship

Zhongguo Jianchuan Yanjiu, 2019
[Objectives] Bolt is usually used in connection for titanium alloy bulbous bow domes of new types of ships and such connection is exposed to bow slamming and wave loading,thus fatigue analysis of titanium-steel connection structure is necessary.[Methods]
SONG Zhenwei, CAO Junwei, LIU Ling, ZHENG Shaowen, XU Feng   +4 more
doaj   +1 more source

The effect of quenching and defects size on the HCF behaviour of Boron steel [PDF]

, 2014
This work investigates the effect of natural and artificial surface defects and quenching on the fatigue strength of a Boron steel (22MnB5). A vast experimental campaign has been undertaken to study the high cycle fatigue behaviour and more specifically ...
ABRIVARD, Benjamin, ABROUG, Foued, DELHAYE, Philippe, MOREL, Franck, PESSARD, Etienne   +4 more
core   +6 more sources

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp, Ludwig Karrasch, Helena Breitenstein, Andreas Straube, Katharina Kamm   +4 more
wiley   +1 more source

Are aerobic fitness and repeated sprint ability linked to fatigue in professional soccer match-play? A pilot study [PDF]

, 2013
This investigation examined the association between aerobic fitness and repeated sprint ability and match-related fatigue in 9 professional outfield soccer players.
Carling, C., Dupont, G., Le Gall, F., McCall, A., Nedelec, M.,   +4 more
core   +1 more source

Advancing Age Modulates Associations Between Cognitive Impairment and Brain Volumes in Early MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Cognitive impairment is common in multiple sclerosis (MS), but manifestations following the first demyelinating event are relatively unexplored. We investigated cross‐sectional associations between magnetic resonance imaging (MRI)–derived brain volumes and the presence of cognitive impairment outcomes five years after the first ...
Piriyankan Ananthavarathan, Marco Pitteri, Michael Foster, Sara Collorone, Sara Salama, Elisa Colato, Ferran Prados, Baris Kanber, Marios Yiannakas, Claudia A. M. Gandini Wheeler‐Kingshott, Indran Davagnanam, Frederik Barkhof, Declan Chard, Olga Ciccarelli, Ahmed Toosy   +14 more
wiley   +1 more source

Method for reproducing deterioration of single-link buffer rubber used in railway vehicles

Nihon Kikai Gakkai ronbunshu
Single-link used in rolling stock are an important component that connects the bogie to the car body. They trail and brake the car body according to the acceleration and deceleration of the bogie.
Shogo MAMADA, Hiroshi TANAKA, Tatsuya OTA, Momoko YOSHIDA   +3 more
doaj   +1 more source

Test analysis on influence of welding defects on fatigue life of aluminum alloy plate frames

Zhongguo Jianchuan Yanjiu, 2019
[Objectives] This paper aims to study the influence of welding defects on fatigue life of aluminum alloy plate frame.[Methods] Firstly,use X-ray to detect the welds of the test aluminum alloy plate frames with two gusset joints,and then select two plate ...
Miao Sufei, Liu Jingxi, Liu Yuandan, Wang Xiulan   +3 more
doaj   +1 more source