Results 171 to 180 of about 11,054 (291)

Methanol intoxication and acute kidney injury: pathophysiological mechanisms and therapeutic approaches. [PDF]

J Bras Nefrol
Nogueira GN, Teles CBM, Varão MVS, Costa AC, Ramos GML, Daher EF.   +5 more
europepmc   +1 more source

GPR124 Alleviates Blood–Brain Barrier Disruption by Enhancing Microvascular Endothelial Function after Traumatic Brain Injury

Advanced Science, EarlyView.
Our study reveals the protective role of GPR124 in maintaining BBB integrity and promoting neurological recovery following TBI. It makes a significant contribution by uncovering a novel molecular interaction between GPR124 and FGFBP1 and linking this to activation of the Wnt/β‐catenin signaling pathway in vascular repair mechanisms.
Chen Wang, Lin Cai, Qiuyuan Gong, Yang Yang, Yuqing Liang, Xinyu Niu, Lai Wei, Ze Liu, Shengju Wu, Yinghui Men, Yaohui Tang, Jun Ding, Hengli Tian, Hao Chen   +13 more
wiley   +1 more source

Empathy and Person-Centered Care from the perspective of undergraduate Speech-Language Pathology students. [PDF]

Codas
Veloso GF, Almeida TF, Fidêncio VLD.
europepmc   +1 more source

High Humidity Exacerbates Psoriasiform Skin Disease Relapse by Increasing Tissue‐Resident Memory T Cells via Altering Skin Microbiota

Advanced Science, EarlyView.
We demonstrated that high humidity worsened psoriasis relapse in murine psoriasiform skin inflammation by increasing skin‐resident memory CD8+ cells via upregulating IL‐15Rα on keratinocytes. The increases in IL‐15Rα and memory CD8+ cells were attributed to S. nepalensis and its metabolite ADMA in skin exposed to high humidity.
Chun‐Ling Liang, Yuchao Chen, Chuanjian Lu, Huazhen Liu, Fenglian Qin, Sisi Dai, Feifei Qiu, Haiming Chen, Weihui Lu, Jonathan S. Bromberg, Zhenhua Dai   +10 more
wiley   +1 more source

The APOL1 gene and kidney transplantation: a review article. [PDF]

J Bras Nefrol
Tavares MG, Requião-Moura L, Queiroga L, Silva Junior HT, Pestana JOM.   +4 more
europepmc   +1 more source

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

Advanced Science, EarlyView.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu, Wen Geng, Zhi Du, Yifan Du, Di Wu, Bide Tong, Huaizhen Liang, Xingyu Zhou, Zixuan Ou, Junyu Wei, Kun Wang, Yu Song, Wenbin Hua, Yan Xu, Wencan Ke, Bingjin Wang, Cao Yang   +16 more
wiley   +1 more source

[Suicidal ideation in urban workers in a large municipality, Bahia State, Brazil]. [PDF]

Cad Saude Publica
Palma TF, Teixeira JRB, Araújo TM.
europepmc   +1 more source

Operadores de Ativação Espectral e Tempo Próprio Efetivo em Circuitos: Derivação pelo Protocolo Ação--Fase do Fator \(G(K)\)

Este trabalho apresenta uma derivação variacional e espectral do fator geométrico \(G(K)\), associado à renormalização de tempo próprio efetivo em interfaces eletromagnéticas, circuitais e geométricas.
openaire   +1 more source

Hospitalização por bronquiolite aguda como fator de risco para sibilância recorrente

Foi realizado um estudo longitudinal para avaliar o papel da hospitalização por bronquiolite aguda como fator de risco para sibilância recorrente. Os participantes foram crianças de uma cidade no sul do Brasil, pertencentes à coorte de 1993.
Fernando C. Barros, Ana Maria B. Menezes, Juraci A. César, Cesar G. Victora, Elaine P. Albernaz   +4 more
core  

QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study

Advanced Science, EarlyView.
The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda, Ada Bernaus Vives, Michał Wojciechowski, Dinh Quoc Huy Pham, Mateusz Chwastyk, Mario Vallejo, Anna Novials, Douglas V. Laurents, Mariano Carrión‐Vázquez   +8 more
wiley   +1 more source