Results 121 to 130 of about 2,963,117 (406)

Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites

Gut, 2020
Objective Non-alcoholic fatty liver disease (NAFLD)-associated hepatocellular carcinoma (HCC) is an increasing healthcare burden worldwide. We examined the role of dietary cholesterol in driving NAFLD–HCC through modulating gut microbiota and its ...
Xiang Zhang, O. Coker, E. Chu, Kaili Fu, H. C. Lau, Yi-Xiang J. Wang, A. Chan, Hong Wei, Xiaoyong Yang, J. Sung, Jun Yu   +10 more
semanticscholar   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Association between eGDR and MASLD and liver fibrosis: a cross-sectional study based on NHANES 2017–2023

Frontiers in Medicine
BackgroundThis study aimed to investigate the association between estimated glucose disposal rate (eGDR) and metabolic dysfunction-associated steatotic liver disease (MASLD), as well as liver fibrosis, using data from the National Health and Nutrition ...
Wenjing Peng, Zeyu Li, Nian Fu
doaj   +1 more source

Endothelial dysfunction in adolescents and young adults with nonalcoholic liver disease [PDF]

, 2019
Nonalcoholic liver disease is a global public health problem that increases cardiovascular morbidity and mortality in these patients. This paper discusses endothelial dysfunction among patients (adolescents and young adults) with nonalcoholic liver ...
Donoiu, Ionuț, Istrătoaie, Octavian, Moise, Cristiana G, Mustafa, Edme R, Rogoveanu, Ion, Tudorașcu, Diana R, TÂRTEA, Georgică C   +6 more
core   +1 more source

Phenotypical heterogeneity linked to adipose tissue dysfunction in patients with type 2 diabetes [PDF]

, 2016
Adipose tissue (AT) inflammation leads to increased free fatty acid (FFA) efflux and ectopic fat deposition, but whether AT dysfunction drives selective fat accumulation in specific sites remains unknown.
ANGELICO, Francesco, BARCHETTA, ILARIA, BARONI, Marco Giorgio, BERTOCCINI, LAURA, CATALANO, Carlo, CAVALLO, Maria Gisella, CIMINI, FLAVIA AGATA, DEL VESCOVO, RICCARDO, FRAIOLI, Antonio, Maria Del Ben,, Martino, Michele Di, Morini, Sergio, POLIMENI, LICIA   +12 more
core   +1 more source

Mortality in Biopsy-Confirmed Nonalcoholic Fatty Liver Disease

Gut, 2020
Objective Population-based data are lacking regarding the risk of overall and cause-specific mortality across the complete histological spectrum of non-alcoholic fatty liver disease (NAFLD).
Tracey G. Simon, B. Roelstraete, H. Khalili, H. Hagström, J. Ludvigsson   +4 more
semanticscholar   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Nonalcoholic fatty liver disease

Gastroenterology, 2002
N 'onalcoholic fatty liver disease (NAFLD) includes a spectrum of hepatic pathology that resembles alcohol-induced liver disease but develops in individuals who are not heavy drinkers. NAFLD is likely to be the most common cause of chronic liver disease in many countries and may also potentiate liver damage induced by other agents, such as alcohol ...
Jeanne M, Clark, Frederick L, Brancati, Anna Mae, Diehl   +2 more
openaire   +5 more sources

Myristic acid potentiates palmitic acid-induced lipotoxicity and steatohepatitis associated with lipodystrophy by sustaning de novo ceramide synthesis. [PDF]

, 2015
Palmitic acid (PA) induces hepatocyte apoptosis and fuels de novo ceramide synthesis in the endoplasmic reticulum (ER). Myristic acid (MA), a free fatty acid highly abundant in copra/palmist oils, is a predictor of nonalcoholic steatohepatitis (NASH) and
Alarcón-Vila, C, Baulies, A, Caballeria, J, Casas, J, Elena, M, Fabriàs, G, Fernandez-Checa, JC, García-Ruiz, C, Martinez Gili, L, Torres, S   +9 more
core   +2 more sources

Association Between Fibrosis Stage and Outcomes of Patients with Non-Alcoholic Fatty Liver Disease: a Systematic Review and Meta-Analysis.

Gastroenterology, 2020
BACKGROUND & AIMS Biopsy-confirmed liver fibrosis is a prognostic factor for patients with non-alcoholic fatty liver disease (NAFLD). We performed a systematic review to quantify the prognostic value of fibrosis stage in patients with NAFLD and the ...
Rod S. Taylor, Rebecca J. Taylor, S. Bayliss, H. Hagström, Patrik Nasr, J. Schattenberg, M. Ishigami, H. Toyoda, V. Wai‐Sun Wong, N. Peleg, A. Shlomai, G. Sebastiani, Yuya Seko, N. Bhala, Z. Younossi, Q. Anstee, S. McPherson, P. Newsome   +17 more
semanticscholar   +1 more source