Results 41 to 50 of about 31,328 (309)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Assessing multi-version systems through fault Injection [PDF]

, 2001
Multi-version design (MVD) has been proposed as a method for increasing the dependability of critical systems beyond current levels. However, a major obstacle to large-scale commercial usage of this approach is the lack of quantitative characterizations ...
Townend, Paul Michael
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

An Energy-Efficient and Cooperative Fault- Tolerant Communication Approach for Wireless Body Area Network

IEEE Access, 2020
The tremendous advancement in embedded systems, miniaturization, and wireless technology had allowed Wireless Body Area Networks (WBAN) to have overwhelming applications in e-healthcare, entertainment, sports/games training, etc.
Gulzar Mehmood, Muhammad Zahid Khan, Sohail Abbas, Mohammad Faisal, Haseeb Ur Rahman   +4 more
doaj   +1 more source

Superconducting fault current limiter application in a power-dense marine electrical system

, 2011
Power-dense, low-voltage marine electrical systems have the potential for extremely high fault currents. Superconducting fault current limiters (SFCLs) have been of interest for many years and offer an effective method for reducing fault currents.
Burt, Graeme, J. McCarthy, Elders, Ian, S.M. Blair, I.M. Elders, Blair, Steven Macpherson, Booth, Campbell, McCarthy, J., Singh, Nand, N.K. Singh, C.D. Booth, G.M. Burt   +11 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Functional Safety Support for the Specialized Computers with Combined Fault-Tolerance Based on the Checkpoints Technique

Безопасность информационных технологий, 2012
The paper considers the issues of functional safety (reliability) support for the specialized computers with combined fault-tolerance. The combined fault-tolerance is analyzed; the criterion is reliable functioning probability.
A. E. Alexandrovich, G. G. Novikov, V. O. Chuckanov, I. M. Yadykin   +3 more
doaj  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Effective load balancing approach in cloud computing using Inspired Lion Optimization Algorithm

e-Prime: Advances in Electrical Engineering, Electronics and Energy, 2023
Load balancing problem is important in cloud computing for effectively managing the cloud resources. It entails distributing incoming network traffic or computational workload among numerous servers so that no single server is overburdened, hence ...
Kaviarasan R, Balamurugan G, Kalaiyarasan R, Venkata Ravindra Reddy Y   +3 more
doaj   +1 more source