Results 51 to 60 of about 31,328 (309)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

A fault line selection method for flexible grounding systems based on zero-sequence current phase variation

Zhejiang dianli
To address the poor tolerance to transitional resistance and incomplete utilization of fault information in grounding protection for flexible grounding systems， a fault line selection method based on current phase variation is proposed.
LI Zong, WANG Deqiang, FENG Liang, SONG Jianguo, GAO Weiyuan, YUAN Pengsheng   +5 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

MODEL BASED SOLUTION FOR COMPUTING CHECKPOINTING INTERVAL FOR FAULT-TOLERANT ROLLBACK-RECOVERY IN ENTERPRISE SERVERS

Journal of Problems in Computer Science and Information Technologies
Recently, reliable information processing has become a relevant topic with the increase of digitalization. It is especially essential for enterprises that process huge amounts of data every day. These processes require stability and reliability as their
Mukhit Zhanuzakov, Gulnar Balakayeva, Paul Ezhilchelvan   +2 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Efficient Point of Load Conversion From the Satellite Main Bus

E3S Web of Conferences, 2017
This paper examines some of the issues involved in the distribution of power from the Main Satellite bus to advanced Mixed Signal Electronics payloads. Trade-offs are described in the design of Bulk voltage conversion vs Point of Load conversion.
Franks Principal Patrick, Gati Tom, DeBauche Jean Louis   +2 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Distributed controller clustering in software defined networks. [PDF]

PLoS ONE, 2017
Software Defined Networking (SDN) is an emerging promising paradigm for network management because of its centralized network intelligence. However, the centralized control architecture of the software-defined networks (SDNs) brings novel challenges of ...
Ahmed Abdelaziz, Ang Tan Fong, Abdullah Gani, Usman Garba, Suleman Khan, Adnan Akhunzada, Hamid Talebian, Kim-Kwang Raymond Choo   +7 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

The Reliability Analysis for Corporative IP-Telephony System with Functional Safety

Безопасность информационных технологий, 2011
The article is devoted to issues of reliability modeling for fault tolerant corporative IP-telephony system. Two reliability models are presented based on the minimal paths and minimal cuts technique. Two reliability models are proposed based on the link
A. E. Alexandrovich, V. O. Chuckanov, I. M. Yadykin   +2 more
doaj