Results 131 to 140 of about 43,176 (313)

Study on development mechanism and variability of strike-slip fault-controlled reservoirs regulated by multi-stage structural stress: a case study of the Shunbei area, Tarim Basin

Shiyou shiyan dizhi
The Shunbei oil-and-gas field in the Tarim Basin features a typical strike-slip fault-controlled fractured-vuggy reservoir. The formation of these reservoirs is primarily influenced by fracturing related to structural stress during periods of fault ...
Jibiao ZHANG, Shang DENG, Jun HAN, Yingtao LI, Dawei LIU, Huabiao QIU, Zhongpei ZHANG, Yuqing LIU   +7 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Fault lines [PDF]

Fault Lines is a dance theatre performance that explores the climate crisis and aims to connect audiences with a deeper care for our planet. The work premiered in February 2024 and will continue to tour into 2025.
Whitaker, Carrie, Mortimer, Abigail
core  

Growth of South Rough Ridge, Central Otago, New Zealand: using in situ cosmogenic isotopes and geomorphology to study an active, blind reverse fault

In situ cosmogenic 10Be and 26Al measurements on sedimentary quartzites, together with analysis of abandoned river terraces, can be used to show how drainage responded to the lateral propagation of a late Quaternary anticline forming above a blind ...
Raisbeck, G. M., Bennett, E. R., Norris, R. J., Yiou, F., Fielding, E., Youngson, J. H., Jackson, J. A.   +6 more
core   +1 more source

New insights into the evolution and formation mechanism of SB5 fault: a case study from the Fuman Oilfield, Tarim basin, NW China

Frontiers in Earth Science
The Shunbei 5 (SB5) strike-slip fault, situated in the central Tarim basin, is distinguished by its considerable length, significant variations in planar orientation, and intricate multi-stage tectonic evolution.
Xingguo Song, Xingguo Song, Shi Chen, Shi Chen, Yintao Zhang, Zhou Xie, Yuan Neng, Yuan Neng, Xinxin Liang, Xinxin Liang, Pengfei Kang, Minghui Yang, Minghui Yang, Ping Chen, Ping Chen   +14 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Tectonic geomorphological evidence of late Quaternary segmented activity along the northern margin fault of Lajishan

Dizhi lixue xuebao
Objective  The Lajishan–Jishishan orogenic belt represents a significant arc-shaped tectonic zone formed by northeastward compressional expansion along the northeastern margin of the Tibetan Plateau, jointly controlled by two compressional thrust fault ...
ZHANG Lijun, YUAN Daoyang, LI Hongqiang, SU Qi, SU Ruihuan, CHEN Yanwen, WEN Yameng   +6 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Bayesian Diagnosability and Active Fault Identification

2025 IEEE 64th Conference on Decision and Control (CDC)
We study fault identification in discrete-time nonlinear systems subject to additive Gaussian white noise. We introduce a Bayesian framework that explicitly accounts for unmodeled faults under reasonable assumptions. Our approach hinges on a new quantitative diagnosability definition, revealing when passive fault identification (FID) is fundamentally ...
Chun-Wei Kong, Jay W. McMahon, Morteza Lahijanian   +2 more
openaire   +2 more sources