Results 111 to 120 of about 43,176 (313)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Fault-insertion and fault-fixing: analysing developer activity over time
, 2020 Developers inevitably make human errors while coding. These errors can lead to faults in code, some of which may result in system failures. It is important to reduce the faults inserted by developers as well as fix any that slip through.
Destefanis G. +4 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
A transverse fault in an extended terrane, the Currant Summit Fault, Nevada
, 2000 Transverse faults in extensional terranes strike parallel to subparallel to the extension direction, are laterally continuous, and terminate abruptly.
Williams, Nathan David
core +1 more source
地震科学进展Based on digital elevation model (DEM), field river terrace survey and optical stimulated luminescence dating (OSL) dating, the slope, relief degree of land surface (RDLS), hypsometric integral (HI) and channel steepness index (Ksn) of the southern ...
Xing’ao Li +4 more
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
As embedded systems become increasingly complex, traditional reliability analysis methods based on text alone are no longer adequate for meeting the requirements of rapid and accurate quantitative analysis of system reliability.
Changyong Chu, Weikang Yang, Yajun Chen
core +1 more source
Remote SensingThe Lijiang–Jinpingshan fault (LJF) is an important secondary boundary fault that obliquely cuts the Sichuan–Yunnan rhombic block. It is of great significance for understanding the tectonic evolution of the Sichuan–Yunnan rhombic block and even the ...
Yongqi Chen +5 more
doaj +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Applied SciencesThe Jining River northern margin fault is a newly discovered Quaternary active fault, located at the junction of the northeastern corner of the Ordos Block and the Yinshan-Yanshan Uplift (Jining District, Ulanqab, Inner Mongolia). The northeastern margin
Haowen Ma, Shaopeng Dong
doaj +1 more source