Results 91 to 100 of about 29,214 (264)

Geomorphological Evidence of Active Faulting on Alluvial Fan Along Northeastern Margin of Tibetan Plateau (NW China)

Remote Sensing
Complete records of fault activity are very valuable for assessing possible earthquakes. Fault scarps are one key to exploring past fault activity. Through the records of fault scarps, we can obtain evidence of fault activity and faulting events in ...
Xianghe Ji, Klaus Reicherter
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Quaternary Segmentation Characteristics of the Hunhe Fault, Northeast China

Applied Sciences
The northern segment of the Tanlu fault zone, which encompasses the Dunhua–Mishan and Yilan–Yitong fault zones, plays a critical role in the tectonic framework of Northeast China. This study focuses on the Hunhe fault, part of the Liaoning segment of the
Bo Wan, Guanghao Ha, Xiaohui Zhao, Rui Suo   +3 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Study on development mechanism and variability of strike-slip fault-controlled reservoirs regulated by multi-stage structural stress: a case study of the Shunbei area, Tarim Basin

Shiyou shiyan dizhi
The Shunbei oil-and-gas field in the Tarim Basin features a typical strike-slip fault-controlled fractured-vuggy reservoir. The formation of these reservoirs is primarily influenced by fracturing related to structural stress during periods of fault ...
Jibiao ZHANG, Shang DENG, Jun HAN, Yingtao LI, Dawei LIU, Huabiao QIU, Zhongpei ZHANG, Yuqing LIU   +7 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

New insights into the evolution and formation mechanism of SB5 fault: a case study from the Fuman Oilfield, Tarim basin, NW China

Frontiers in Earth Science
The Shunbei 5 (SB5) strike-slip fault, situated in the central Tarim basin, is distinguished by its considerable length, significant variations in planar orientation, and intricate multi-stage tectonic evolution.
Xingguo Song, Xingguo Song, Shi Chen, Shi Chen, Yintao Zhang, Zhou Xie, Yuan Neng, Yuan Neng, Xinxin Liang, Xinxin Liang, Pengfei Kang, Minghui Yang, Minghui Yang, Ping Chen, Ping Chen   +14 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Tectonic geomorphological evidence of late Quaternary segmented activity along the northern margin fault of Lajishan

Dizhi lixue xuebao
Objective  The Lajishan–Jishishan orogenic belt represents a significant arc-shaped tectonic zone formed by northeastward compressional expansion along the northeastern margin of the Tibetan Plateau, jointly controlled by two compressional thrust fault ...
ZHANG Lijun, YUAN Daoyang, LI Hongqiang, SU Qi, SU Ruihuan, CHEN Yanwen, WEN Yameng   +6 more
doaj   +1 more source