Results 151 to 160 of about 43,176 (313)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Neotectonic activity on the Carcavai fault zone (Algarve, Portugal) [PDF]

open access: yes, 2011
Studies performed on the Carcavai fault zone, Eastern Algarve, revealed several deformational features in Plio-Quaternary sediments with potential neotectonic implications.
Cabral, João   +6 more
core  

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

An empirical investigation into contributory factors of change and fault propensity in large-scale commercial object-oriented software

open access: yes, 2012
This thesis was submitted for the degree of Doctor of Philosophy and was awarded by Brunel UniversityObject-Oriented design and development dominates both commercial and open source software projects.
Gatrell, Matt
core  

ACTIVE FAULT MAPPING AND PHOTOGRAMMETRICAL ANALYSIS OF FAULTING ACTIVITIES IN MONGOLIA

open access: yesACTIVE FAULT MAPPING AND PHOTOGRAMMETRICAL ANALYSIS OF FAULTING ACTIVITIES IN MONGOLIA
形態: カラー図版あり 形態: DVD-ROM1枚 Physical characteristics: Original contains color illustrations Note: One DVD-ROM 資料番号: AA0065135141 レポート番号: JAXA-SP-11 ...
openaire  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Evaluation of a fuzzy-expert system for fault diagnosis in power systems

open access: yes
A major problem with alarm processing and fault diagnosis in power systems is the reliance on the circuit alarm status. If there is too much information available and the time of arrival of the information is random due to weather conditions etc., the ...
Park, Min Young
core  

Kashima fault as a model fault for active fault segmentation

open access: yesActive Fault Research, 2002
Sato, Takayuki, Nakata, Takashi
openaire   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

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