Results 91 to 100 of about 35,187 (315)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
From model, signal to knowledge: a data-driven perspective of fault detection and diagnosis [PDF]
, 2013 This review paper is to give a full picture of fault detection and diagnosis (FDD) in complex systems from the perspective of data processing. As a matter of fact, an FDD system is a data-processing system on the basis of information redundancy, in which
Dai, Xuewu, Gao, Zhiwei
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Rough set based gas turbine fault isolation study [PDF]
, 2010 Gas path fault isolation is one of the key techniques in Engine Health Management systems. In order to accomplish gas path fault isolation successfully for a gas turbine engine, both an accurate off-design performance model and an effective fault ...
Wang, Lihui.
core
An Online Classification Method for Fault Diagnosis of Railway Turnouts
, 2020 Railway turnout system is a key infrastructure to railway safety and efficiency. However, it is prone to failure in the field. Therefore, many railway departments have adopted a monitoring system to monitor the operation status of turnouts.
Dongxiu Ou, Hu Liu, Lei Zhang, Yuqing Ji
core +1 more source
Fault Classification in Predictive Maintenance
, 2023 Abstract In the field of predictive maintenance, “smart condition monitoring” extends beyond merely assessing the present state of manufacturing equipment. In today's landscape, businesses and research endeavors strive for deeper insights into equipment conditions, seeking to uncover potential causes behind issues or anticipate the remaining ...
Guenter Roehrich, Davide Raffaele
openaire +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
"Selection of Input Parameters for Multivariate Classifiersin Proactive Machine Health Monitoring by Clustering Envelope Spectrum Harmonics" [PDF]
, 2015 In condition monitoring (CM) signal analysis the inherent problem of key characteristics being masked by noise can be addressed by analysis of the signal envelope.
Gu, Fengshou, Ball, Andrew, Smith, Ann
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Semisupervised classification for fault diagnosis in nuclear power plants
Nuclear Engineering and Technology, 2015 Pattern classifications have become important tools for fault diagnosis in nuclear power plants (NPP). However, it is often difficult to obtain training data under fault conditions to train a supervised classification model.
Jianping Ma, Jin Jiang
doaj +1 more source