Results 81 to 90 of about 2,214,988 (289)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Two-Stage Fault Classification Algorithm for Real Fault Data in Transmission Lines

IEEE Access
Fault classification in power transmission lines is important in distance relaying for identifying the accurate phases implicated in the fault occurrence.
Se-Heon Lim, Taegeun Kim, Kyeong-Yeong Lee, Kyung-Min Song, Sung-Guk Yoon   +4 more
doaj   +1 more source

Fault Classification in Predictive Maintenance

, 2023
Abstract In the field of predictive maintenance, “smart condition monitoring” extends beyond merely assessing the present state of manufacturing equipment. In today's landscape, businesses and research endeavors strive for deeper insights into equipment conditions, seeking to uncover potential causes behind issues or anticipate the remaining ...
Guenter Roehrich, Davide Raffaele
openaire   +1 more source

Paleoearthquakes of the Düzce fault (North Anatolian Fault Zone): Insights for large surface faulting earthquake recurrence [PDF]

, 2008
Copyright 2008 by the American Geophysical Union.The 12 November 1999 Mw 7.1 earthquake ruptured the Düzce segment of the North Anatolian Fault Zone and produced a ∼40-km-long surface rupture.
D. Pantosti, Palyvos, N, S. Pucci, C. Zabci, D'Addezio, G, N. Palyvos, Zabci, C, De Martini, PM, Zabci, C., Pucci, S, G. D'Addezio, Pucci, S., D'Addezio, G., Pantosti, D., P. E. F. Collins, Palyvos, N., P. M. De Martini, De Martini, P. M., Pantosti, D, Collins, PEF, Collins, P. E. F.   +20 more
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Neural Architecture Search for Bearing Fault Classification

Proceedings of the 16th International Conference on Agents and Artificial Intelligence
In this research, we address bearing fault classification by evaluating three neural network models: 1D Convolutional Neural Network (1D-CNN), CNN-Visual Geometry Group (CNN-VGG), and Long Short-Term Memory (LSTM). Utilizing vibration data, our approach incorporates data augmentation to address the limited availability of fault class data.
Edicson Santiago Bonilla Diaz, Enrique Naredo, Nicolas Francisco Mateo Díaz, Douglas Mota Dias, Maria Alejandra Bonilla Diaz, Susan Harnett, Conor Ryan   +6 more
openaire   +2 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

A Study of Motor Bearing Fault Diagnosis using Modulation Signal Bispectrum Analysis of Motor Current Signals [PDF]

, 2013
Failure of induction motors are a large concern due to its influence over industrial production. Motor current signature analysis (MCSA) is common practice in industry to find motor faults. This paper presents a new approach to detection and diagnosis of
Chen, Zhi, Gu, Fengshou, Ball, Andrew, Alwodai, Ahmed, Wang, Tie, Cattley, Robert   +5 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source