Results 71 to 80 of about 2,331,494 (299)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Research on Four-Quadrant Input Over-current Fault Diagnosis of Electric Locomotive Based on Recursive 2-Classification Method

机车电传动, 2019
Four-quadrant over-current fault is one of the main faults of the HXD1 locomotive traction converter. Due to the class distribution of fault cause is unbalanced and there are a lot of over-current fault causes, four-quadromt over-current fault is ...
Jianhua WANG
doaj  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Leveraging generative adversarial networks for data augmentation to improve fault detection in wind turbines with imbalanced data

Results in Engineering
In the realm of modern power systems, wind turbines (WTs) have gained significant environmental advantages, making them pivotal in the expanding landscape of wind power generation.
Subhajit Chatterjee, Yung-Cheol Byun
doaj   +1 more source

Induction machine fault detection enhancement using a stator current high resolution spectrum [PDF]

, 2012
Fault detection in squirrel cage induction machines based on stator current spectrum has been widely investigated. Several high resolution spectral estimation techniques have been developed and used to detect induction machine abnormal operating ...
CHARPENTIER, Jean-Frederic, Vincent Choqueuse, EL BOUCHIKHI, El Houssin, BENBOUZID, Mohamed, Choqueuse, Vincent, V., Mohamed Benbouzid, El Houssin El Bouchikhi, Jean Frederic Charpentier, CHOQUEUSE, Vincent   +8 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

FisPro based interpretable fuzzy inference system for dual circuit extra high voltage transmission line fault classification and fault distance estimation [PDF]

Journal of Fuzzy Extension and Applications
Accurate fault classification and precise fault distance estimation play a critical role in reliable, stable and optimal operation of electrical power systems.
A Naresh Kumar, Sajja Suneel, Bharathi Gururaj, Muktevi Chakravarthy, Mortha Suresh Kumar, Muniyappa Ramesha, Elemasetty Uday Kiran, Malleboina Nagaraju   +7 more
doaj   +1 more source

Embedded-Fault-Tolerant-Control/RotationForest-FDI-Dataset: v1.0

, 2023
Dataset for CASE23 paper on "Fault Detection and Isolation on a Hexacopter UAV using a Two-stage classification method"
Prudhvi Raj Turlapati, Munjaal Bhatt, Mayank Singh, Aditya Mulgundkar   +3 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source