Results 51 to 60 of about 22,860 (267)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Rolling Bearing Fault Diagnosis Method Based on Fusion of CNN and CSSVM

Journal of Harbin University of Science and Technology
Aiming at the problems of low classification accuracy and weak model generalization ability of traditional fault diagnosis classification methods in the fault diagnosis of rolling bearings in rotating machinery, an intelligent fault diagnosis model based
LI Yunfeng, LAN Xiaosheng, SHEN Hongchang, XU Tongle   +3 more
doaj   +1 more source

Faults Classification Of Power Electronic Circuits Based On A Support Vector Data Description Method

Metrology and Measurement Systems, 2015
Power electronic circuits (PECs) are prone to various failures, whose classification is of paramount importance. This paper presents a data-driven based fault diagnosis technique, which employs a support vector data description (SVDD) method to perform ...
Cui Jiang
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Performance Comparison Between Deep Learning Models for Fault Classification in Transmission Lines Using Time Series Data

Energy Science & Engineering
Deep learning has become a vital tool for addressing complex challenges in power systems, particularly fault detection and classification in transmission lines. This study presents a comparative analysis of three advanced time‐series models like temporal
Nadeem Ahmed Tunio, Mohsin Ali Tunio, Muhammad Amir Raza, Muhammad Faheem, Ashfaque Ahmed Hashmani, Rumaisa Nadeem   +5 more
doaj   +1 more source

Fault Handling in Industry 4.0: Definition, Process and Applications

Sensors, 2022
The increase of productivity and decrease of production loss is an important goal for modern industry to stay economically competitive. For that, efficient fault management and quick amendment of faults in production lines are needed.
Heiko Webert, Tamara Döß, Lukas Kaupp, Stephan Simons   +3 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Research on fault diagnosis method of aviation cable based on improved Adaboost

Advances in Mechanical Engineering, 2022
In order to solve the problems of short circuit, open circuit and insulation faults in aviation cables, a fault diagnosis method based on BP-Adaboost algorithm is proposed in this paper.
Falin Wang, Gang Yuan, Chaoyang Guo, Zhinong Li   +3 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

A Comparative Study of Time–Frequency Representations for Bearing and Rotating Fault Diagnosis Using Vision Transformer

Machines
This paper presents a comparative analysis of bearing and rotating component fault classification based on different time–frequency representations using vision transformer (ViT). Four different time–frequency transformation techniques—short-time Fourier
Ahmet Orhan, Nikolay Yordanov, Merve Ertarğın, Marin Zhilevski, Mikho Mikhov   +4 more
doaj   +1 more source