Results 71 to 80 of about 3,519,795 (189)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

The effect of structural preservation conditions on pore structure of marine shale reservoir: a case study of the Wufeng-Longmaxi Formation shale, Southern Sichuan Basin, China

Frontiers in Earth Science
The marine shale within the Sichuan Basin constitutes China’s significant shale gas production, featuring old formation age, high degree of thermal evolution, multiple tectonic movements, and complex structural conditions.
Weiming Yu, Weiming Yu, Shusheng Yuan, Shusheng Yuan, Haoxuan Tang, Haoxuan Tang, Chao Luo, Chao Luo, Wei Wu, Wei Wu, Jia Liu, Jia Liu, Yuran Yang, Yuran Yang, Kesu Zhong, Kesu Zhong, Liang He, Liang He   +17 more
doaj   +1 more source

Fault-Tolerant Operation of an Open-End Winding Five-Phase PMSM Drive with Inverter Faults [PDF]

, 2013
The authors would like to thank the ADEME for the funding of the MHYGALE project.Multi-phase machines are known for their fault-tolerant capability. However, star-connected machines have no fault tolerance to inverter switch short-circuit fault.
NGUYEN, Ngac Ky, Ngac-Ky Nguyen, KESTELYN, Xavier, SEMAIL, Eric, Paul Sandulescu, Eric Semail, Nguyen, Ngac-Ky, SANDULESCU, Paul, MEINGUET, Fabien, Fabien Meinguet, Xavier Kestelyn   +10 more
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

First fracture characteristics of main roof plate structure with goaf (coal pillar) on both sides and elastic-plastic foundation boundary

Meitan xuebao
In order to study the fracture position and engineering significance of the main roof plate structure under the condition of goaf on both sides (coal pillars), the double plasticized foundation boundary mechanical model of the main roof plate structure ...
Dongdong CHEN, Zijian LI, Shengrong XIE, Fulian HE, Yu LUO, Zaisheng JIANG, Xiang MA, Hui LI   +7 more
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

An online-integrated condition monitoring and prognostics framework for rotating equipment [PDF]

, 2014
Detecting abnormal operating conditions, which will lead to faults developing later, has important economic implications for industries trying to meet their performance and production goals.
Alrabady, Linda Antoun Yousef
core   +3 more sources

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source