Results 101 to 110 of about 832,201 (307)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Research on Fault Diagnosis of UAV Rotor Motor Bearings Based on WPT-CEEMD-CNN-LSTM

Machines
To address the challenge of extracting adaptive fault features for unmanned aerial vehicle (UAV) rotor motor bearings and to meet the high accuracy requirements of bearing fault diagnosis, this paper proposes a neural network-based bearing fault ...
Xianyi Shang, Wei Li, Fang Yuan, Haifeng Zhi, Zhilong Gao, Min Guo, Bo Xin   +6 more
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Visual Process Monitoring by Data-Dependent Kernel Discriminant Analysis with t‑Distributed Similarities

ACS Omega, 2023
Chihang Wei, Chenglin Wen, Jieguang He, Zhihuan Song   +3 more
doaj   +1 more source

Strong coupling between a single-photon and a two-photon Fock state

Nature Communications
The realization of strong nonlinear coupling between single photons has been a long-standing goal in quantum optics and quantum information science, promising wide impact applications, such as all-optical deterministic quantum logic and single-photon ...
Shuai-Peng Wang, Alberto Mercurio, Alessandro Ridolfo, Yuqing Wang, Mo Chen, Wenyan Wang, Yulong Liu, Huanying Sun, Tiefu Li, Franco Nori, Salvatore Savasta, J. Q. You   +11 more
doaj   +1 more source

Analysis of multiple lightning overvoltage on 110 kV transmission lines

Results in Engineering
As pointed out by the CIGRE TB 549 report issued by the International Power Grid Committee, >80 % of cloud-to-ground lightning are multiple lightning strokes (MLS), posing a severe threat to overhead transmission lines.
Yutao Tang, Haoming Liu, Hongchun Shu, Yue Dai, Yiming Han   +4 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Quasi-single phase permanent fault identification method and reclosing strategy based on multi-level confidence rules

International Journal of Electrical Power & Energy Systems
As global temperatures rise, the frequency of lightning increases, making lightning one of the principal threats to power-system security. Field incidents indicate that, within the automatic reclosing time window, multiple-stroke lightning can exhibit ...
Hongchun Shu, Baisong Liu, Weijie Lou, Yutao Tang, Haoming Liu, Yiming Han, Yue Dai, Ying Cao   +7 more
doaj   +1 more source

Finite Time Fault Tolerant Attitude Control-Based Observer for a Rigid Satellite Subject to Thruster Faults

IEEE Access, 2017
A rigid satellite fault diagnosis strategy, subject to faults of external disturbances and thruster faults, is developed. In this design, an equivalent idea is introduced to design a sliding mode observer that can detect and identify the failures ...
A. Aihua Zhang, B. Chengcong Lv, C. Zhiqiang Zhang, D. Zhiyong She   +3 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source