Results 71 to 80 of about 55,562 (265)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Two basic ways to realise DC circuit breakers
The Journal of Engineering, 2019 As a key element of the DC grid, the technology of DC circuit breakers (DCCBs) still have difficulty to be widely used due to its large cost and volume. This paper studies the basic principle and its realisation methods for DCCBs.
Zheng Xu +3 more
doaj +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Optimal power flow considering fault current level constraints and fault current limiters
International Journal of Electrical Power & Energy Systems, 2014 Abstract The aim of this paper is to present a novel method to dispatch the active generation power properly in the power system while incorporating fault current levels as constraints for the optimization problem. Due to the limited capacity of protective devices such as circuit breakers, allocating active power without considering fault current ...
Amirhossein Khazali, Mohsen Kalantar
openaire +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Reliability Evaluation and Improvement of Smart Grid Generations Based on Smart Fault Current Controller in Presence of Renewable Energies [PDF]
SVU-International Journal of Engineering Sciences and ApplicationsRenewable energy sources are considered the perfect solution to solve the problem of increasing electrical energy demand nowadays. However, minimizing the effects of electrical faults is very important to achieve reliability.
M. Nasrallah +3 more
doaj +1 more source
Suppression of Fault Currents on DG Using Various Fault Current Limiters in Distribution Network [PDF]
Journal of Electrical & Electronic Systems, 2013 Protection of Distributed Generation (DG) is a challenging task in entire electrical family. DG plays a vital role in advanced power systems engineering. The connection of DG to the distribution network has numerous advantages. Even though it has a advantages, while connecting the DG with existing power system network, the fault current level in many ...
openaire +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source