Results 131 to 140 of about 3,149,182 (297)
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Descriptor system techniques in solving H2/H-infinity optimal fault detection and isolation problems. [PDF]
, 2012 This chapter illustrates the effectiveness of descriptor systems based algorithms in solving H2/H-infinity optimal fault detection and isolation problems.
Varga, A
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Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
A comparative analysis of fault detection schemes for stochastic continuous-time dynamical systems [PDF]
, 2008 This paper addresses a comparative analysis of the existing schemes for fault detection in continuous-time stochastic dynamical systems. Such schemes prove to be efficient when dealing with specific types of fault functions; on the other hand, they show ...
Zufiria Zatarain, Pedro José
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Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Descriptor system techniques in solving H2/infinity-optimal fault detection and isolation problems [PDF]
, 2012 This chapter illustrates the effectiveness of descriptor systems based algorithms in solving H2/infinity-optimal fault detection and isolation problems.
Varga, Andreas
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Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
Application of Adaptive Thresholds in Robust Fault Detection of an Electro-Mechanical Single-Wheel Steering Actuator [PDF]
, 2012 A fault detection scheme has been developed for an electromechanical steering actuator under closed-loop control. The closed-loop system is modeled as a 2nd order system with bounded parameter uncertainties given by the performance specifications.
Ho, Lok Man
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