Results 91 to 100 of about 101,205 (396)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Time-Varying Fault Diagnosis for Asynchronous Multisensor Systems Based on Augmented IMM and Strong Tracking Filtering

Journal of Control Science and Engineering, 2018
A fault detection, isolation, and estimation approach is proposed in this paper based on Interactive Multimodel (IMM) fusion filtering and Strong Tracking Filtering (STF) for asynchronous multisensors dynamic systems. Time-varying fault is considered and
Yanyan Hu, Xiaoling Xue, Zengwang Jin, Kaixiang Peng   +3 more
doaj   +1 more source

Usage of Fault Detection Isolation & Recovery (FDIR) in Constellation (CxP) Launch Operations [PDF]

, 2010
This paper will explore the usage of Fault Detection Isolation & Recovery (FDIR) in the Constellation Exploration Program (CxP), in particular Launch Operations at Kennedy Space Center (KSC).
Brown, Barbara, Ferrell, Rob, Hall, David, Lewis, Mark, Oostdyk, Rebecca, Perotti, Jose, Spirkovska, Lilly   +6 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Machine Current Sensor FDI Strategy in PMSMs

IEEE Access, 2019
This work proposes a machine current sensor fault detection and isolation (FDI) strategy in permanent magnet synchronous machines (PMSMs) resilient to multiple faults.
Haibo Li, Yi Qian, Sohrab Asgarpoor, Hamid Sharif   +3 more
doaj   +1 more source

Fault Detection and Isolation of Linear Impulsive Systems

IEEE Transactions on Automatic Control, 2009
This technical note investigates the development of fault detection and isolation (FDI) filters for linear impulsive systems. The concept of an unobservability subspace is introduced for linear impulsive systems and an algorithm for its construction is described.
Meskin, Nader, Khorasani, K.
openaire   +3 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

ResFaultyMan: An intelligent fault detection predictive model in power electronics systems using unsupervised learning isolation forest

Heliyon
Intelligent fault detection considered as a paramount importance in Power Electronics Systems (PELS) to ensure operational reliability along with rising complexities and critical application demands.
Ashkan Safari, Mehran Sabahi, Arman Oshnoei   +2 more
doaj   +1 more source

State-Space GMDH Neural Networks for Actuator Robust Fault Diagnosis

Advances in Electrical and Computer Engineering, 2012
Most fault diagnosis methods focus on the fault detection of the system or sensors and do not take into account the problem of the fault detection and isolation of the actuators, which are an important part of the contemporary industrial systems.
MRUGALSKI, M., WITCZAK, M.
doaj   +1 more source

Fault detection and isolation [PDF]

Erroneous measurements in multisensor navigation systems must be detected and isolated. A recursive estimator can find fast growing errors; a least squares batch estimator can find slow growing errors. This process is called fault detection. A protection
Bernath, Greg
core   +1 more source