Results 81 to 90 of about 5,365 (259)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Noninvasive Methods for Fault Detection and Isolation in Internal Combustion Engines Based on Chaos Analysis. [PDF]
Sensors (Basel), 2021 Lima TLV +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Multi-Sensor Fault Detection, Identification, Isolation and Health Forecasting for Autonomous Vehicles. [PDF]
Sensors (Basel), 2021 Safavi S, Safavi MA, Hamid H, Fallah S.
europepmc +1 more source
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
Model-Based Fault Detection and Isolation of a Liquid-Cooled Frequency Converter on a Wind Turbine
Journal of Control Science and Engineering, 2012 With the rapid development of wind energy technologies and growth of installed wind turbine capacity in the world, the reliability of the wind turbine becomes an important issue for wind turbine manufactures, owners, and operators. The reliability of the
Peng Li +4 more
doaj +1 more source
A Particle Filtering Approach for Fault Detection and Isolation of UAV IMU Sensors: Design, Implementation and Sensitivity Analysis. [PDF]
Sensors (Basel), 2021 D'Amato E +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Design of Fault Detection, Isolation and Accommodation Algorithm for Attitude Determination System of a 3-Axis Satellite [PDF]
فصلنامه علوم و فناوری فضایی, 2012 In this study, a fault tolerant Attitude Determination System (ADS) has been designed which provides fault detection, isolation and tolerant abilities in this system.
S. S. Nasrolahi, H. Bolandi, M. Abedi
doaj
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source