Results 71 to 80 of about 5,365 (259)
Fault Detection, Isolation and Reconfiguration of Four-Bar Mechanism-Based Knee Exoskeleton
SensorsKnee exoskeletons are sophisticated wearable devices engineered to aid or augment human movement, especially in rehabilitation and mobility assistance contexts.
Prakhar Jain +4 more
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
An Integrated Simulation Method for Built-in Test System Based on Stateflow
Chemical Engineering Transactions, 2013 To satisfy the application requirements of built-in test (BIT) technology in equipment design for testability and prognostic and health management (PHM), an integrated simulation method for BIT system based on stateflow is proposed. Based on the analysis
X.G. Lin, J.Y. Shi, L. Chen
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Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Bearing fault detection with application to PHM Data Challenge [PDF]
International Journal of Prognostics and Health Management, 2011 Mechanical faults in production lines can result in partial or total breakdown of a production line, destruction of equipment and even catastrophes. Implementation of an adequate fault detection system represents an important step towards early detection
Anton Urevc, Pavle Boškoski
doaj
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
AlgorithmsThis paper addresses fault diagnosis in nonlinear systems where reliable mathematical models are unavailable and only input–output measurements are accessible. The proposed methodology consists of three stages.
Julio-Alberto Guzmán-Rabasa +6 more
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Fault Detection and Isolation of Non-Gaussian and Nonlinear Processes Based on Statistics Pattern Analysis and the k-Nearest Neighbor Method. [PDF]
ACS Omega, 2022 Zhou Z, Wang J, Yang C, Wen C, Li Z.
europepmc +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source