Results 91 to 100 of about 8,566 (306)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A framework and methods for on-board network level fault diagnostics in automobiles [PDF]

A significant number of electronic control units (ECUs) are nowadays networked in automotive vehicles to help achieve advanced vehicle control and eliminate bulky electrical wiring.
Suwatthikul, Jittiwut
core  

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

A Method for Fault Detection and Diagnostics in Ventilation Units Using Virtual Sensors

Sensors, 2018
Buildings represent a significant portion of global energy consumption. Ventilation units are complex components, often customized for the specific building, responsible for a large part of energy consumption.
Claudio Giovanni Mattera, Joseba Quevedo, Teresa Escobet, Hamid Reza Shaker, Muhyiddine Jradi   +4 more
doaj   +1 more source

New strategies for fault tolerant control and fault diagnostic

IFAC Proceedings Volumes, 2003
Abstract A recent architecture based on the Youla parameterization is analyzed for the nominal and uncertain case. This special architecture is characterized by a separation principle for the controller. In this paper, several stability results that allow to extend the structure to the integrated control/filter approach are presented.
Andrés Marcos, Subhabrata Ganguli, Gary J. Balas   +2 more
openaire   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

A non-linear weighted least squares gas turbine diagnostic approach and multi-fuel performance simulation [PDF]

, 2011
The gas turbine which has found numerous applications in Air, Land and Sea applications, as a propulsion system, electricity generator and prime mover, is subject to deterioration of its individual components.
Kamunge, Daniel
core  

An overview of PST for vibration based fault diagnostics in rotating machinery

MATEC Web of Conferences, 2018
In general, diagnostics can be defined as the procedure of mapping the information obtained in the measurement space to the presence and magnitude of faults in the fault space.
Mohamad T. Haj, Nataraj C.
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source