Results 51 to 60 of about 788,688 (243)
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Online Fault-Tolerant Onboard Aeroengine Model Tuning Structure
International Journal of Aerospace Engineering, 2016 Online onboard aeroengine models (OBEMs) have been widely used in health management, fault diagnostics, and fault-tolerant control. A mismatch between the OBEM and the actual engine may be caused by a variety of factors such as health degradation or ...
Shuiting Ding +3 more
doaj +1 more source
Sensors, 2015 As train loads and travel speeds have increased over time, railway axle bearings have become critical elements which require more efficient non-destructive inspection and fault diagnostics methods. This paper presents a novel and adaptive procedure based
Cai Yi +3 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
The comparison of fault distinguishability approaches – case study [PDF]
Bulletin of the Polish Academy of Sciences: Technical Sciences, 2019 A comprehensive characterization of four selected fault distinguishability methods is presented herein. All considered methods are derived from structural residual approaches referring to model-based diagnostics. In particular, these methods are based on
J.M. Kościelny, M. Bartyś, K. Rostek
doaj +1 more source
Sensors, 2022 A complete surveillance strategy for wind turbines requires both the condition monitoring (CM) of their mechanical components and the structural health monitoring (SHM) of their load-bearing structural elements (foundations, tower, and blades). Therefore,
Marco Civera, Cecilia Surace
doaj +1 more source
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Architecting an Agent-Based Fault Diagnosis Engine for IEC 61499 Industrial Cyber-Physical Systems
Future Internet, 2021 IEC 61499 is a reference architecture for constructing Industrial Cyber-Physical Systems (ICPS). However, current function block development environments only provide limited fault-finding capabilities.
Barry Dowdeswell +2 more
doaj +1 more source
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source