Results 61 to 70 of about 16,975 (265)
Search-Based Prediction of Fault Count Data [PDF]
2009 1st International Symposium on Search Based Software Engineering, 2009 Symbolic regression, an application domain of genetic programming (GP), aims to find a function whose output has some desired property, like matching target values of a particular data set. While typical regression involves finding the coefficients of a pre-defined function, symbolic regression finds a general function, with coefficients, fitting the ...
Afzal, Wasif +2 more
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Fault Classification in Predictive Maintenance
, 2023 Abstract In the field of predictive maintenance, “smart condition monitoring” extends beyond merely assessing the present state of manufacturing equipment. In today's landscape, businesses and research endeavors strive for deeper insights into equipment conditions, seeking to uncover potential causes behind issues or anticipate the remaining ...
Guenter Roehrich, Davide Raffaele
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Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Diance yu yibiaoThere are many potential fault risks in distribution automation system. If the fault is not diagnosed in time, the power supply quality will be affected.
WU Longteng, HE Jianjun, GUO Qian
doaj +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Estimating System State through Similarity Analysis of Signal Patterns
Sensors, 2020 State prediction is not straightforward, particularly for complex systems that cannot provide sufficient amounts of training data. In particular, it is usually difficult to analyze some signal patterns for state prediction if they were observed in both ...
Kichang Namgung +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source