Results 71 to 80 of about 1,965,454 (227)

Research of fault diagnosis and prediction for diesel engine based on probabilistic neural network

Gong-kuang zidonghua, 2013
In view of problem of difficult fault diagnosis and prediction for diesel engine, the paper analyzed common faults and influencing factors of diesel engine, introduced method of extraction, analysis and processing of the failure data, and built a model ...
ZHENG Xiao-qian, HU Shi-qiang, WU Jian
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Prediction Model of Vibration Feature for Equipment Maintenance Based on Full Vector Spectrum

Shock and Vibration, 2017
Establishing a prediction model is a key step for the implementation of prognostic and health management. The prediction model can be used to forecast the change trend of the characteristics of the vibration signal and analyze the potential failure in ...
Lei Chen, Jie Han, Wenping Lei, ZhenHong Guan, Yajuan Gao   +4 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Cascading fault path prediction of large-scale wind power grid-connected system based on bi-level multi-objective decision

Diance yu yibiao
The uncertainty of wind power output increases the difficulty of cascading fault path prediction. Therefore, this paper proposes a cascading fault path prediction method for large-scale wind power grid-connected system based on bi-level multi-objective ...
WU Yuhang, LIU Xiangyu, WANG Tao, GU Xueping   +3 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Research on fault time prediction method for high speed rail BTM unit based on multi method interactive validation

High-Speed Railway
The Balise Transmission Module (BTM) unit of the on-board train control system is a crucial component. Due to its unique installation position and complex environment, this unit has a higher fault rate within the on-board train control system. To conduct
Limin Fu, Junqiang Gou, Chao Sun, Hanrui Li, Wei Liu   +4 more
doaj   +1 more source

Remaining Useful Life Prediction and Fault Diagnosis of Rolling Bearings Based on Short-Time Fourier Transform and Convolutional Neural Network

Shock and Vibration, 2020
Rolling bearings play a pivotal role in rotating machinery. The remaining useful life prediction and fault diagnosis of bearings are crucial to condition-based maintenance.
Shuang Zhou, Maohua Xiao, Petr Bartos, Martin Filip, Guosheng Geng   +4 more
doaj   +1 more source