Results 71 to 80 of about 236,153 (262)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

An Efficient Fault-Tolerant Scheduling Approach with Energy Minimization for Hard Real-Time Embedded Systems

Cybernetics and Information Technologies, 2019
In this paper, we focus on two major problems in hard real-time embedded systems fault tolerance and energy minimization. Fault tolerance is achieved via both checkpointing technique and active replication strategy to tolerate multiple transient faults ...
Kada Barkahoum, Kalla Hamoudi
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Unifying flavors of fault tolerance with the ZX calculus [PDF]

Quantum
There are several models of quantum computation which exhibit shared fundamental fault-tolerance properties. This article makes commonalities explicit by presenting these different models in a unifying framework based on the ZX calculus.
Hector Bombin, Daniel Litinski, Naomi Nickerson, Fernando Pastawski, Sam Roberts   +4 more
doaj   +1 more source

Beyond Optimal Fault Tolerance

The optimal fault-tolerance achievable by any protocol has been characterized in a wide range of settings. For example, for state machine replication (SMR) protocols operating in the partially synchronous setting, it is possible to simultaneously guarantee consistency against $α$-bounded adversaries (i.e., adversaries that control less than an $α ...
Lewis-Pye, Andrew, Roughgarden, Tim
openaire   +4 more sources

Fault-tolerant compass codes

Physical Review A, 2020
We study a class of gauge fixings of the Bacon-Shor code at the circuit level, which includes a subfamily of generalized surface codes. We show that for these codes, fault tolerance can be achieved by direct measurements of the stabilizers. By simulating our fault-tolerant scheme under biased noise, we show the possibility of optimizing the performance
Shilin Huang, Kenneth R. Brown
openaire   +4 more sources

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Measuring the BDARX architecture by agent oriented system a case study [PDF]

, 2018
Distributed systems are progressively designed as multi-agent systems that are helpful in designing high strength complex industrial software. Recently, distributed systems cooperative applications are openly access, dynamic and large scales.
Abdul Hamid, Noorhamreeza, Khan, Sundas Naqeeb, Mohd Nawi, Nazri, Rahman, Atta-ur-, Shahzad, Asim, Ullah, Arif, Witjaksono, R Wahjoe   +6 more
core  

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source