Results 31 to 40 of about 204,063 (261)

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Development and implementation of preventive-maintenance practices in Nigerian industries.

, 2006
A methodology for the development of PM using the modern approaches of FMEA, root-cause analysis, and fault-tree analysis is presented. Applying PM leads to a cost reduction in maintenance and less overall energy expenditure.
Eti, Mark C., Ogaji, S. O. T., Probert, S. D.   +2 more
core   +1 more source

Uncertainty handling in quantitative BDD-based fault-tree analysis by interval computation [PDF]

, 2011
In fault-tree analysis probabilities of failure of components are often assumed to be precise. However this assumption is seldom verified in practice. There is a large literature on the computation of the probability of the top (dreadful) event of the ...
Cardoso, Janette, Dubois, Didier, Jacob, Christelle   +2 more
core   +2 more sources

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Energy dependence of the GAFCHROMIC LD‐V1 in the diagnostic radiographic modalities

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract The GAFCHROMIC LD‐V1 radiochromic film is widely used in dosimetry because it can provide high‐resolution two‐dimensional dose distributions without processing. This study aimed to evaluate the response characteristics at different effective energies, from the low‐energy range of mammography to the high‐energy range of computed tomography. Net
Tatsuhiro Gotanda, Tomoyuki Hasuo, Shinnosuke Nishihara, Kohsei Matsuura, Yasuyuki Kawaji, Hidetoshi Yatake, Shinya Imai, Takuya Akagawa, Nobuyoshi Tanki, Toshizo Katsuda   +9 more
wiley   +1 more source

Approximate dynamic fault tree calculations for modelling water supply risks [PDF]

, 2012
Traditional fault tree analysis is not always sufficient when analysing complex systems. To overcome the limitations dynamic fault tree (DFT) analysis is suggested in the literature as well as different approaches for how to solve DFTs.
Lindhe, Andreas, Norberg, Tommy, Rosén, Lars   +2 more
core   +1 more source

Bridging Nature and Technology: A Perspective on Role of Machine Learning in Bioinspired Ceramics

Advanced Engineering Materials, EarlyView.
Machine learning (ML) is revolutionizing the development of bioinspired ceramics. This article investigates how ML can be used to design new ceramic materials with exceptional performance, inspired by the structures found in nature. The research highlights how ML can predict material properties, optimize designs, and create advanced models to unlock a ...
Hamidreza Yazdani Sarvestani, Aditi Singh, Behnam Ashrafi   +2 more
wiley   +1 more source

ANALISIS PENYEBAB KEGAGALAN KOMPONEN RADIO KAYU DI CV. PIRANTI WORK [PDF]

, 2011
Failure occurs when the workpiece stop doing one or more functions that should be good before self service expected to achieve, it can be said workpiece fails or is damaged. Failure can affect the output of production.
Dwi Artati, Desti
core  

Simulation of Inhomogeneous Refractive Index Fields Induced by Hot Tailored Forming Components

Advanced Engineering Materials, EarlyView.
This article presents a simulation model for simulating inhomogeneous refractive index fields (IRIF) in hot‐forged components, accounting for thermal influences and complex geometries. Through this simulation, a priori knowledge about the propagation of the IRIF can be obtained, allowing for the positioning of the component or an optical measurement ...
Pascal Kern, Lennart Hinz, Markus Kästner, Eduard Reithmeier   +3 more
wiley   +1 more source

DFTCalc: A Tool for Efficient Fault Tree Analysis [PDF]

, 2013
Effective risk management is a key to ensure that our nuclear power plants, medical equipment, and power grids are dependable; and it is often required by law. Fault Tree Analysis (FTA) is a widely used methodology here, computing important dependability measures like system reliability.
Arnold F., Belinfante A., Van Der Berg F., Guck D., Stoelinga M.   +4 more
openaire   +2 more sources