Results 41 to 50 of about 24,244,078 (287)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
ANALYSIS OF THE FAULT TREE OF THE CROP SPRAYER PUMP [PDF]
Proceedings on Engineering Sciences, 2019 Using the Fault Tree Analysis method - FTA, an analysis of the potential failure modes of the elements of the crop sprayer pump Comet BP 105 was carried out in this paper. In order to conduct a detailed analysis of the causes and failure modes of a pump,
Dobrivoje Ćatić +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Model based fault tree analysis. [PDF]
, 2019 Fault Tree Analysis (FTA) is one of the most important processes to ensure safety and reliability in systems engineering when developing high-hazard systems. Currently, traceability is being ensured by using document-based methods.
Ružauskas, Lukas,
core +1 more source
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Heterotropic regulation and negative homotropic cooperativity
FEBS Open Bio, EarlyView.We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
From Fault Tree to Credit Risk Assessment: A Case Study [PDF]
Reliability has been largely applied to industrial systems in order to study the various possibilities of systems’ failure. The goal is to establish the chain of events leading to any system’s failure, namely the top event.
Hayette Gatfaoui
core +2 more sources
Application of Fault Tree Analysis Technique Based on Isograph to Railway Vehicles
机车电传动, 2011 By taking the saloon door unexpectedly opening of the train on the main line as the top event, the fault tree based on Isograph was established and the fault tree analysis was carried out.
张丽娜, 武彤, 刘金安, 王金田
doaj
IEEE Open Journal of the Industrial Electronics Society, 2023 Fault diagnosis is integral to maintenance practices, ensuring optimal machinery functionality. While traditional methods relied on human expertise, intelligent fault diagnosis techniques, propelled by machine learning (ML) advancements, now offer ...
Sina Yousefi +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey +4 more
wiley +1 more source