Results 51 to 60 of about 19,544,767 (297)

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

Fuzzy fault diagnostic system based on fault tree analysis [PDF]

open access: yes, 1995
A method is presented for process fault diagnosis using information from fault tree analysis and uncertainty/imprecision of data. Fault tree analysis, which has been used as a method of system reliability/safety analysis, provides a procedure for ...
Suzuki, Kazuhiko   +7 more
core   +1 more source

Heterotropic regulation and negative homotropic cooperativity

open access: yesFEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea   +5 more
wiley   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

open access: yesFEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey   +4 more
wiley   +1 more source

Fault Tree Analysis for Robust Design

open access: yesDesigns
The objective of this research is to incorporate system failure into a robust design formation and solution process. The system failure referred to here will be built using fault tree analysis (FTA), which will take all lower-level failure events into ...
Jonathan DeGroff, Gene Jean-Win Hou
doaj   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

open access: yesFEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan   +2 more
wiley   +1 more source

Risk Analysis Using HAZOP -Fault Tree - Event Tree Methodology Case Study: Naphta Stabilizer-A Reflux Drum (LPG separation) in RA1K

open access: yesAlgerian Journal of Signals and Systems, 2020
The purpose of this work is the risk assessment of a stabilizer reflux drum using HAZOP - Fault tree - Event tree approach. This risk assessment approach aims first of all to identify potential accident scenarios using Hazard an Operability study (HAZOP)
Seif El Islam Bouasla   +2 more
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

open access: yesAging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif   +17 more
wiley   +1 more source

THE FAULT TREE ANALYSIS OF AIRCRAFT HYDRAULIC BRAKE SYSTEM BASED ON HYPER-ELLIPSOIDAL MODEL

open access: yesJixie qiangdu, 2017
In fault tree analysis of aircraft hydraulic brake system,the probability statistical information of failure rate for bottom event is usually not sufficient.To solve this problem,a fault tree analysis method based on hyper-ellipsoidal model was given ...
ZHANG LeiLei   +4 more
doaj  

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